Immunosuppressants drugs - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.94 [0.73, 1.20]< 121%11 studies (11/-)68.9 %highcritical lowcrucial-
clinical deterioration 0.79 [0.58, 1.08]< 117%5 studies (5/-)93.0 %some concernnot evaluable moderateimportant-
clinical improvement 1.34 [1.13, 1.60]> 136%7 studies (7/-)99.9 %highnot evaluable lowimportant-
clinical improvement (28-day) 1.19 [0.81, 1.75]> 10%1 study (1/-)81.0 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.15 [0.90, 1.47]> 10%1 study (1/-)86.8 %some concernnot evaluable moderateimportant-
death or ventilation 0.73 [0.54, 0.99]< 130%7 studies (7/-)97.9 %highnot evaluable lowimportant-
hospital discharge 1.16 [0.90, 1.49]> 10%1 study (1/-)87.9 %some concernnot evaluable moderateimportant-
ventilation 0.43 [0.17, 1.12]< 159%3 studies (3/-)95.7 %highnot evaluable lowimportant-
off oxygenation 1.46 [0.79, 2.68]> 128%2 studies (2/-)88.7 %highnot evaluable lownon important-

safety endpoints 00

superinfection 0.77 [0.48, 1.23]< 10%1 study (1/-)86.0 %some concernnot evaluable moderateimportant-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.