corticosteroids - versus placebo - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.92 [0.67, 1.28]< 10%1 study (1/-)68.5 %some concernnot evaluable moderatecrucial-
death or ventilation 0.71 [0.37, 1.35]< 10%1 study (1/-)85.3 %lownot evaluable highimportant-
ventilation 0.95 [0.44, 2.04]< 10%1 study (1/-)55.3 %lownot evaluable highimportant-

safety endpoints 00

superinfection 0.81 [0.49, 1.34]< 10%1 study (1/-)79.2 %lownot evaluable highimportant-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.