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corticosteroids - versus placebo - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.98 [0.93, 1.02]< 10%2 studies (2/-)85.3 %some concernnot evaluable moderatecrucial-
deaths 0.91 [0.73, 1.14]< 144%3 studies (3/-)78.7 %some concernnot evaluable moderatecrucial-
clinical deterioration 1.00 [0.13, 7.45]< 10%1 study (1/-)50.0 %NAnot evaluable important-
clinical improvement 1.04 [0.67, 1.62]> 10%1 study (1/-)57.5 %NAnot evaluable important-
clinical improvement (14-day) 1.33 [0.57, 3.11]> 10%1 study (1/-)74.2 %NAnot evaluable important-
clinical improvement (time to event analysis only) 1.04 [0.67, 1.62]> 10%1 study (1/-)57.5 %NAnot evaluable important-
death or ventilation 0.71 [0.37, 1.35]< 10%1 study (1/-)85.3 %NAnot evaluable important-
hospital discharge 1.67 [0.87, 3.19]> 10%1 study (1/-)93.9 %NAnot evaluable important-
mechanical ventilation 1.06 [0.62, 1.81]< 10%2 studies (2/-)41.0 %some concernnot evaluable moderateimportant-
viral clearance 1.78 [1.06, 3.00]> 10%1 study (1/-)98.5 %NAnot evaluable important-
viral clearance (time to event analysis only) 1.78 [1.06, 3.00]> 10%1 study (1/-)98.5 %NAnot evaluable important-
ICU admission 1.00 [0.13, 7.45]< 10%1 study (1/-)50.0 %NAnot evaluable non important-

safety endpoints 00

superinfection 0.91 [0.66, 1.25]< 10%2 studies (2/-)72.5 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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