remdesivir - versus placebo - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.77 [0.54, 1.09]< 10%2 studies (2/-)93.0 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.70 [0.47, 1.04]< 10%1 study (1/-)96.1 %some concernnot evaluable moderatecrucial-
clinical improvement 1.30 [1.12, 1.51]> 10%2 studies (2/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.21 [0.64, 2.28]> 10%1 study (1/-)71.9 %lownot evaluable highimportant-
clinical improvement (28-day) 1.37 [0.79, 2.39]> 10%1 study (1/-)86.8 %lownot evaluable highimportant-
clinical improvement (7-day) 0.99 [0.18, 5.51]> 10%1 study (1/-)49.4 %lownot evaluable highimportant-
clinical improvement (time to event analysis only) 1.23 [0.87, 1.74]> 10%1 study (1/-)87.7 %lownot evaluable highimportant-

safety endpoints 00

AE leading to drug discontinuation 2.43 [0.79, 7.45]< 10%1 study (1/-)6.0 %lownot evaluable highimportant-
serious adverse events 0.71 [0.55, 0.92]< 10%2 studies (2/-)99.5 %some concernnot evaluable moderateimportant-
deep vein thrombosis 0.62 [0.23, 1.64]< 10%2 studies (2/-)83.1 %some concernnot evaluable moderatenon important-
elevated liver enzymes 0.58 [0.34, 0.97]< 16%2 studies (2/-)98.1 %some concernnot evaluable moderatenon important-
hyperbilirubinemia 0.97 [0.48, 1.93]< 10%2 studies (2/-)53.8 %some concernnot evaluable moderatenon important-
pulmonary embolism 0.82 [0.20, 3.29]< 10%2 studies (2/-)61.1 %some concernnot evaluable moderatenon important-
renal impairment 1.02 [0.64, 1.61]< 10%2 studies (2/-)47.2 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.