colchicine - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.01 [0.95, 1.07]< 10%5 studies (5/-)41.7 %some concernserious moderatecrucial-
deaths 1.00 [0.95, 1.06]< 10%8 studies (8/-)45.4 %some concernserious moderatecrucial-
hospitalization or death 0.81 [0.62, 1.04]< 10%2 studies (2/-)95.1 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.27 [0.08, 0.90]< 10%2 studies (2/-)98.3 %some concernnot evaluable moderateimportant-
death or ventilation 1.02 [0.96, 1.09]< 10%1 study (1/-)27.1 %some concernnot evaluable moderateimportant-
hospital discharge 0.98 [0.94, 1.03]> 10%1 study (1/-)19.3 %some concernnot evaluable moderateimportant-
hospitalization 0.85 [0.54, 1.35]< 114%2 studies (2/-)75.0 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.87 [0.66, 1.13]< 154%5 studies (5/-)85.9 %some concernserious moderateimportant-
ICU admission 0.92 [0.54, 1.58]< 10%2 studies (2/-)61.6 %some concernnot evaluable moderatenon important-
recovery 0.92 [0.72, 1.17]> 10%1 study (1/-)24.7 %some concernnot evaluable moderatenon important-

safety endpoints 00

related AE (TRAE) 1.74 [1.50, 2.03]< 10%1 study (1/-)0.0 %lownot evaluable highimportant-
serious adverse events 0.77 [0.59, 0.99]< 10%2 studies (2/-)97.8 %some concernnot evaluable moderateimportant-
adverse events 1.72 [0.73, 4.08]< 10%1 study (1/-)10.9 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.