chloroquine and derivatives - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 1.10 [0.99, 1.22]< 10%13 studies (13/-)4.6 %some concernlow moderatecrucial-
deaths (time to event analysis only) 1.10 [0.99, 1.23]< 10%2 studies (2/-)3.9 %some concernnot evaluable moderatecrucial-
clinical deterioration 1.07 [0.62, 1.85]< 125%2 studies (2/-)40.7 %some concernnot evaluable moderateimportant-
clinical improvement 1.13 [0.86, 1.48]> 11%2 studies (2/-)81.5 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.17 [0.62, 2.23]> 120%2 studies (2/-)68.6 %some concernnot evaluable moderateimportant-
death or ventilation 1.14 [1.03, 1.25]< 10%3 studies (3/-)0.5 %some concernnot evaluable moderateimportant-
hospitalization 0.79 [0.42, 1.48]< 10%2 studies (2/-)77.0 %some concernnot evaluable moderateimportant-
PCR-negative conversion 0.46 [0.04, 5.75]> 10%1 study (1/-)27.7 %some concernnot evaluable moderateimportant-
PCR-negative conversion (14-day) 1.42 [0.26, 7.76]> 10%1 study (1/-)65.5 %some concernnot evaluable moderateimportant-
ICU admission 0.83 [0.35, 1.95]< 10%1 study (1/-)66.8 %some concernnot evaluable moderatenon important-

safety endpoints 00

cardiac arrest 1.92 [0.35, 10.49]< 10%1 study (1/-)22.7 %some concernnot evaluable moderateimportant-
adverse events 2.20 [0.92, 5.29]< 193%7 studies (7/-)3.9 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.