ACTION, 2021 NCT04332107
azithromycin (n=171) vs. placebo (n=92)
randomized controlled trial
some concerns about risk of bias
azithromycin
oral azithromycin : a single 1.2g dose PO
placebo
COVID 19 outpatients
patients must be able to return internet-based study questionnaires
Double blind.
Across the United States.
PRINCIPLE, 2021 ISRCTN86534580
azithromycin (n=540) vs. standard of care (n=875)
randomized controlled trial
some concerns about risk of bias
azithromycin 500 mg daily for three days plus usual care
usual care alone
3 arms: usual care plus azithromycin 500 mg daily for three days, usual care plus other interventions, or usual care alone
COVID 19 outpatients
open-label
nationwide, UK
Hinks (ATOMIC2), 2021 NCT04381962
azithromycin (n=147) vs. standard of care (n=148)
randomized controlled trial
some concerns about risk of bias
azithromycin
500 mg once daily for 14 days
standard of care
COVID 19 outpatients
open label
19 centers, UK
800 patients anticipated 298 included, primary outcome was updated after the pre-planned interim analysis and sample size was adapted