meta|Evidence - COVID-19
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niclosamide (n=75) vs. standard of care (n=75)
randomized controlled trial some concerns about risk of bias
Niclosamide (NCS)
Standard of care plus NCS: NCS 2 grams orally loading dose chewable then 1g every 12 hours were admisntered in the first day, then on the 2nd day; 1g x3 for 7 days. (Only in the first day 4 gm/d then on the second day 3g/d in 3 divided doses for 7 days).
Standard of care
SoC only.
Standard of care inluded all or some of thr following, according to the clinical condition of each patient: Acetaminophen, vitamin C, zinc, ivermectin, doxycyclin, favipiravir, vitamin D3, azithromycin, oxygen therapy, dexamethasone or methylprednisolone, mechanical ventilation.
COVID 19 hospitalized
Patients with age above 18 years and of any gender with a definite diagnosis of COVID-19 according to the WHO classification criteria. Patients symptomatic for no more than three days for mild-moderate cases, no more than two days after being severe cases, and no more than one day after being critical cases.
Open-label.
2 hospitals in Baghdad city, Iraq.
The physician will check for the following: Fever: axillary temperature ≤36.6 ◦C or oral temperature ≤37.2 ◦C; Respiratory rate: ≤24/minute on room air; Oxygen saturation: >94% on room air; Cough: mild or absent on a patient reported scale of severe, moderate, mild, absent.) and elevated D-dimer, C reactive pro-tein, ferritin, thrombocyte, PT, aPTT, and fibrinogen were associated with a poor outcome in COVID19. These parameters will be checked on day 1 and day 3
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