hight dose vitamin D (n=130) vs. Vitamin D (n=130)
randomized controlled trial
high risk of bias
high dose vitamin D3 (400,000 IU)
single oral high dose of cholecalciferol (vitamin D3) administered within 72 hours after the diagnosis of COVID-19
standard-dose vitamin D3 (50,000 IU)
COVID-19 mild to moderate
≥65 years, had SARS-CoV-2 infection of less than 3 days, and at least 1 COVID-19 worsening risk factor (among age ≥75 years, SpO2 ≤94%, or PaO2/FiO2 ≤300 mm Hg)
open-label
9 medical centers in France
ambiguous results table for mortality with 3 analysis methods without mention of the preplanned primary analysis. Whatever, the 14-days censured cox result is not robust given the others 14 days and 28 days results (in particular the 14-days death *rate* comparison, probable preplanned primary analysis according to the published protocol)