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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

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insufficient data

Interactive explorer of NMA results

anti-interleukin-6 vs. baricitinib plus remdesivir 1.35 [0.76; 2.41]1.35 [0.76;2.41]anti-interleukin-6 vs. baricitinib plus remdesivir 1.35 [0.76; 2.41]anti-interleukin-6 vs. colchicine 2.59 [0.37; 18.20]2.59 [0.37;18.20]anti-interleukin-6 vs. colchicine 2.59 [0.37; 18.20]anti-interleukin-6 vs. control 0.80 [0.64; 1.00]0.80 [0.64;1.00]anti-interleukin-6 vs. control 0.80 [0.64; 1.00]anti-interleukin-6 vs. convalescent plasma treatment 1.01 [0.59; 1.73]1.01 [0.59;1.73]anti-interleukin-6 vs. convalescent plasma treatment 1.01 [0.59; 1.73]anti-interleukin-6 vs. corticosteroids 0.91 [0.71; 1.16]0.91 [0.71;1.16]anti-interleukin-6 vs. corticosteroids 0.91 [0.71; 1.16]anti-interleukin-6 vs. hydroxychloroquine 0.75 [0.59; 0.96]0.75 [0.59;0.96]anti-interleukin-6 vs. hydroxychloroquine 0.75 [0.59; 0.96]anti-interleukin-6 vs. interferon 0.69 [0.52; 0.93]0.69 [0.52;0.93]anti-interleukin-6 vs. interferon 0.69 [0.52; 0.93]anti-interleukin-6 vs. lopinavir/ritonavir 0.79 [0.62; 1.02]0.79 [0.62;1.02]anti-interleukin-6 vs. lopinavir/ritonavir 0.79 [0.62; 1.02]anti-interleukin-6 vs. remdesivir 0.88 [0.67; 1.15]0.88 [0.67;1.15]anti-interleukin-6 vs. remdesivir 0.88 [0.67; 1.15]anti-interleukin-6 vs. Vitamin D 0.77 [0.27; 2.20]0.77 [0.27;2.20]anti-interleukin-6 vs. Vitamin D 0.77 [0.27; 2.20]baricitinib plus remdesivir vs. anti-interleukin-6 0.74 [0.41; 1.32]0.74 [0.41;1.32]baricitinib plus remdesivir vs. anti-interleukin-6 0.74 [0.41; 1.32]baricitinib plus remdesivir vs. colchicine 1.91 [0.26; 14.29]1.91 [0.26;14.29]baricitinib plus remdesivir vs. colchicine 1.91 [0.26; 14.29]baricitinib plus remdesivir vs. control 0.59 [0.35; 1.01]0.59 [0.35;1.01]baricitinib plus remdesivir vs. control 0.59 [0.35; 1.01]baricitinib plus remdesivir vs. convalescent plasma treatment 0.75 [0.36; 1.54]0.75 [0.36;1.54]baricitinib plus remdesivir vs. convalescent plasma treatment 0.75 [0.36; 1.54]baricitinib plus remdesivir vs. corticosteroids 0.67 [0.39; 1.16]0.67 [0.39;1.16]baricitinib plus remdesivir vs. corticosteroids 0.67 [0.39; 1.16]baricitinib plus remdesivir vs. hydroxychloroquine 0.56 [0.32; 0.96]0.56 [0.32;0.96]baricitinib plus remdesivir vs. hydroxychloroquine 0.56 [0.32; 0.96]baricitinib plus remdesivir vs. interferon 0.51 [0.29; 0.90]0.51 [0.29;0.90]baricitinib plus remdesivir vs. interferon 0.51 [0.29; 0.90]baricitinib plus remdesivir vs. lopinavir/ritonavir 0.59 [0.34; 1.01]0.59 [0.34;1.01]baricitinib plus remdesivir vs. lopinavir/ritonavir 0.59 [0.34; 1.01]baricitinib plus remdesivir vs. remdesivir 0.65 [0.39; 1.09]0.65 [0.39;1.09]baricitinib plus remdesivir vs. remdesivir 0.65 [0.39; 1.09]baricitinib plus remdesivir vs. Vitamin D 0.57 [0.18; 1.81]0.57 [0.18;1.81]baricitinib plus remdesivir vs. Vitamin D 0.57 [0.18; 1.81]colchicine vs. anti-interleukin-6 0.39 [0.05; 2.72]0.39 [0.05;2.72]colchicine vs. anti-interleukin-6 0.39 [0.05; 2.72]colchicine vs. baricitinib plus remdesivir 0.52 [0.07; 3.90]0.52 [0.07;3.90]colchicine vs. baricitinib plus remdesivir 0.52 [0.07; 3.90]colchicine vs. control 0.31 [0.04; 2.15]0.31 [0.04;2.15]colchicine vs. control 0.31 [0.04; 2.15]colchicine vs. convalescent plasma treatment 0.39 [0.05; 2.88]0.39 [0.05;2.88]colchicine vs. convalescent plasma treatment 0.39 [0.05; 2.88]colchicine vs. corticosteroids 0.35 [0.05; 2.45]0.35 [0.05;2.45]colchicine vs. corticosteroids 0.35 [0.05; 2.45]colchicine vs. hydroxychloroquine 0.29 [0.04; 2.03]0.29 [0.04;2.03]colchicine vs. hydroxychloroquine 0.29 [0.04; 2.03]colchicine vs. interferon 0.27 [0.04; 1.88]0.27 [0.04;1.88]colchicine vs. interferon 0.27 [0.04; 1.88]colchicine vs. lopinavir/ritonavir 0.31 [0.04; 2.13]0.31 [0.04;2.13]colchicine vs. lopinavir/ritonavir 0.31 [0.04; 2.13]colchicine vs. remdesivir 0.34 [0.05; 2.37]0.34 [0.05;2.37]colchicine vs. remdesivir 0.34 [0.05; 2.37]colchicine vs. Vitamin D 0.30 [0.03; 2.66]0.30 [0.03;2.66]colchicine vs. Vitamin D 0.30 [0.03; 2.66]control vs. anti-interleukin-6 1.25 [1.00; 1.57]1.25 [1.00;1.57]control vs. anti-interleukin-6 1.25 [1.00; 1.57]control vs. baricitinib plus remdesivir 1.69 [0.99; 2.88]1.69 [0.99;2.88]control vs. baricitinib plus remdesivir 1.69 [0.99; 2.88]control vs. colchicine 3.23 [0.46; 22.43]3.23 [0.46;22.43]control vs. colchicine 3.23 [0.46; 22.43]control vs. convalescent plasma treatment 1.26 [0.77; 2.06]1.26 [0.77;2.06]control vs. convalescent plasma treatment 1.26 [0.77; 2.06]control vs. corticosteroids 1.14 [1.04; 1.24]1.14 [1.04;1.24]control vs. corticosteroids 1.14 [1.04; 1.24]control vs. hydroxychloroquine 0.94 [0.85; 1.04]0.94 [0.85;1.04]control vs. hydroxychloroquine 0.94 [0.85; 1.04]control vs. interferon 0.87 [0.72; 1.04]0.87 [0.72;1.04]control vs. interferon 0.87 [0.72; 1.04]control vs. lopinavir/ritonavir 0.99 [0.89; 1.10]0.99 [0.89;1.10]control vs. lopinavir/ritonavir 0.99 [0.89; 1.10]control vs. remdesivir 1.10 [0.95; 1.27]1.10 [0.95;1.27]control vs. remdesivir 1.10 [0.95; 1.27]control vs. Vitamin D 0.96 [0.34; 2.68]0.96 [0.34;2.68]control vs. Vitamin D 0.96 [0.34; 2.68]convalescent plasma treatment vs. anti-interleukin-6 0.99 [0.58; 1.70]0.99 [0.58;1.70]convalescent plasma treatment vs. anti-interleukin-6 0.99 [0.58; 1.70]convalescent plasma treatment vs. baricitinib plus remdesivir 1.34 [0.65; 2.76]1.34 [0.65;2.76]convalescent plasma treatment vs. baricitinib plus remdesivir 1.34 [0.65; 2.76]convalescent plasma treatment vs. colchicine 2.56 [0.35; 18.91]2.56 [0.35;18.91]convalescent plasma treatment vs. colchicine 2.56 [0.35; 18.91]convalescent plasma treatment vs. control 0.79 [0.49; 1.29]0.79 [0.49;1.29]convalescent plasma treatment vs. control 0.79 [0.49; 1.29]convalescent plasma treatment vs. corticosteroids 0.90 [0.55; 1.48]0.90 [0.55;1.48]convalescent plasma treatment vs. corticosteroids 0.90 [0.55; 1.48]convalescent plasma treatment vs. hydroxychloroquine 0.75 [0.45; 1.23]0.75 [0.45;1.23]convalescent plasma treatment vs. hydroxychloroquine 0.75 [0.45; 1.23]convalescent plasma treatment vs. interferon 0.69 [0.41; 1.16]0.69 [0.41;1.16]convalescent plasma treatment vs. interferon 0.69 [0.41; 1.16]convalescent plasma treatment vs. lopinavir/ritonavir 0.78 [0.47; 1.29]0.78 [0.47;1.29]convalescent plasma treatment vs. lopinavir/ritonavir 0.78 [0.47; 1.29]convalescent plasma treatment vs. remdesivir 0.87 [0.52; 1.45]0.87 [0.52;1.45]convalescent plasma treatment vs. remdesivir 0.87 [0.52; 1.45]convalescent plasma treatment vs. Vitamin D 0.76 [0.24; 2.37]0.76 [0.24;2.37]convalescent plasma treatment vs. Vitamin D 0.76 [0.24; 2.37]corticosteroids vs. anti-interleukin-6 1.10 [0.86; 1.40]1.10 [0.86;1.40]corticosteroids vs. anti-interleukin-6 1.10 [0.86; 1.40]corticosteroids vs. baricitinib plus remdesivir 1.49 [0.87; 2.55]1.49 [0.87;2.55]corticosteroids vs. baricitinib plus remdesivir 1.49 [0.87; 2.55]corticosteroids vs. colchicine 2.85 [0.41; 19.80]2.85 [0.41;19.80]corticosteroids vs. colchicine 2.85 [0.41; 19.80]corticosteroids vs. control 0.88 [0.81; 0.96]0.88 [0.81;0.96]corticosteroids vs. control 0.88 [0.81; 0.96]corticosteroids vs. convalescent plasma treatment 1.11 [0.67; 1.83]1.11 [0.67;1.83]corticosteroids vs. convalescent plasma treatment 1.11 [0.67; 1.83]corticosteroids vs. hydroxychloroquine 0.83 [0.73; 0.94]0.83 [0.73;0.94]corticosteroids vs. hydroxychloroquine 0.83 [0.73; 0.94]corticosteroids vs. interferon 0.76 [0.62; 0.94]0.76 [0.62;0.94]corticosteroids vs. interferon 0.76 [0.62; 0.94]corticosteroids vs. lopinavir/ritonavir 0.87 [0.76; 1.00]0.87 [0.76;1.00]corticosteroids vs. lopinavir/ritonavir 0.87 [0.76; 1.00]corticosteroids vs. remdesivir 0.97 [0.82; 1.14]0.97 [0.82;1.14]corticosteroids vs. remdesivir 0.97 [0.82; 1.14]corticosteroids vs. Vitamin D 0.84 [0.30; 2.37]0.84 [0.30;2.37]corticosteroids vs. Vitamin D 0.84 [0.30; 2.37]hydroxychloroquine vs. anti-interleukin-6 1.33 [1.04; 1.70]1.33 [1.04;1.70]hydroxychloroquine vs. anti-interleukin-6 1.33 [1.04; 1.70]hydroxychloroquine vs. baricitinib plus remdesivir 1.79 [1.04; 3.09]1.79 [1.04;3.09]hydroxychloroquine vs. baricitinib plus remdesivir 1.79 [1.04; 3.09]hydroxychloroquine vs. colchicine 3.43 [0.49; 23.91]3.43 [0.49;23.91]hydroxychloroquine vs. colchicine 3.43 [0.49; 23.91]hydroxychloroquine vs. control 1.06 [0.96; 1.18]1.06 [0.96;1.18]hydroxychloroquine vs. control 1.06 [0.96; 1.18]hydroxychloroquine vs. convalescent plasma treatment 1.34 [0.81; 2.21]1.34 [0.81;2.21]hydroxychloroquine vs. convalescent plasma treatment 1.34 [0.81; 2.21]hydroxychloroquine vs. corticosteroids 1.21 [1.06; 1.37]1.21 [1.06;1.37]hydroxychloroquine vs. corticosteroids 1.21 [1.06; 1.37]hydroxychloroquine vs. interferon 0.92 [0.75; 1.14]0.92 [0.75;1.14]hydroxychloroquine vs. interferon 0.92 [0.75; 1.14]hydroxychloroquine vs. lopinavir/ritonavir 1.05 [0.90; 1.22]1.05 [0.90;1.22]hydroxychloroquine vs. lopinavir/ritonavir 1.05 [0.90; 1.22]hydroxychloroquine vs. remdesivir 1.17 [0.98; 1.39]1.17 [0.98;1.39]hydroxychloroquine vs. remdesivir 1.17 [0.98; 1.39]hydroxychloroquine vs. Vitamin D 1.02 [0.36; 2.86]1.02 [0.36;2.86]hydroxychloroquine vs. Vitamin D 1.02 [0.36; 2.86]interferon vs. anti-interleukin-6 1.44 [1.08; 1.92]1.44 [1.08;1.92]interferon vs. anti-interleukin-6 1.44 [1.08; 1.92]interferon vs. baricitinib plus remdesivir 1.94 [1.11; 3.42]1.94 [1.11;3.42]interferon vs. baricitinib plus remdesivir 1.94 [1.11; 3.42]interferon vs. colchicine 3.72 [0.53; 26.07]3.72 [0.53;26.07]interferon vs. colchicine 3.72 [0.53; 26.07]interferon vs. control 1.15 [0.96; 1.38]1.15 [0.96;1.38]interferon vs. control 1.15 [0.96; 1.38]interferon vs. convalescent plasma treatment 1.45 [0.86; 2.45]1.45 [0.86;2.45]interferon vs. convalescent plasma treatment 1.45 [0.86; 2.45]interferon vs. corticosteroids 1.31 [1.07; 1.60]1.31 [1.07;1.60]interferon vs. corticosteroids 1.31 [1.07; 1.60]interferon vs. hydroxychloroquine 1.08 [0.88; 1.34]1.08 [0.88;1.34]interferon vs. hydroxychloroquine 1.08 [0.88; 1.34]interferon vs. lopinavir/ritonavir 1.14 [0.92; 1.41]1.14 [0.92;1.41]interferon vs. lopinavir/ritonavir 1.14 [0.92; 1.41]interferon vs. remdesivir 1.26 [1.00; 1.59]1.26 [1.00;1.59]interferon vs. remdesivir 1.26 [1.00; 1.59]interferon vs. Vitamin D 1.10 [0.39; 3.13]1.10 [0.39;3.13]interferon vs. Vitamin D 1.10 [0.39; 3.13]lopinavir/ritonavir vs. anti-interleukin-6 1.26 [0.98; 1.63]1.26 [0.98;1.63]lopinavir/ritonavir vs. anti-interleukin-6 1.26 [0.98; 1.63]lopinavir/ritonavir vs. baricitinib plus remdesivir 1.71 [0.99; 2.94]1.71 [0.99;2.94]lopinavir/ritonavir vs. baricitinib plus remdesivir 1.71 [0.99; 2.94]lopinavir/ritonavir vs. colchicine 3.27 [0.47; 22.79]3.27 [0.47;22.79]lopinavir/ritonavir vs. colchicine 3.27 [0.47; 22.79]lopinavir/ritonavir vs. control 1.01 [0.91; 1.13]1.01 [0.91;1.13]lopinavir/ritonavir vs. control 1.01 [0.91; 1.13]lopinavir/ritonavir vs. convalescent plasma treatment 1.28 [0.77; 2.11]1.28 [0.77;2.11]lopinavir/ritonavir vs. convalescent plasma treatment 1.28 [0.77; 2.11]lopinavir/ritonavir vs. corticosteroids 1.15 [1.00; 1.32]1.15 [1.00;1.32]lopinavir/ritonavir vs. corticosteroids 1.15 [1.00; 1.32]lopinavir/ritonavir vs. hydroxychloroquine 0.95 [0.82; 1.11]0.95 [0.82;1.11]lopinavir/ritonavir vs. hydroxychloroquine 0.95 [0.82; 1.11]lopinavir/ritonavir vs. interferon 0.88 [0.71; 1.09]0.88 [0.71;1.09]lopinavir/ritonavir vs. interferon 0.88 [0.71; 1.09]lopinavir/ritonavir vs. remdesivir 1.11 [0.93; 1.33]1.11 [0.93;1.33]lopinavir/ritonavir vs. remdesivir 1.11 [0.93; 1.33]lopinavir/ritonavir vs. Vitamin D 0.97 [0.34; 2.73]0.97 [0.34;2.73]lopinavir/ritonavir vs. Vitamin D 0.97 [0.34; 2.73]remdesivir vs. anti-interleukin-6 1.14 [0.87; 1.49]1.14 [0.87;1.49]remdesivir vs. anti-interleukin-6 1.14 [0.87; 1.49]remdesivir vs. baricitinib plus remdesivir 1.54 [0.92; 2.57]1.54 [0.92;2.57]remdesivir vs. baricitinib plus remdesivir 1.54 [0.92; 2.57]remdesivir vs. colchicine 2.94 [0.42; 20.56]2.94 [0.42;20.56]remdesivir vs. colchicine 2.94 [0.42; 20.56]remdesivir vs. control 0.91 [0.79; 1.05]0.91 [0.79;1.05]remdesivir vs. control 0.91 [0.79; 1.05]remdesivir vs. convalescent plasma treatment 1.15 [0.69; 1.92]1.15 [0.69;1.92]remdesivir vs. convalescent plasma treatment 1.15 [0.69; 1.92]remdesivir vs. corticosteroids 1.04 [0.87; 1.22]1.04 [0.87;1.22]remdesivir vs. corticosteroids 1.04 [0.87; 1.22]remdesivir vs. hydroxychloroquine 0.86 [0.72; 1.02]0.86 [0.72;1.02]remdesivir vs. hydroxychloroquine 0.86 [0.72; 1.02]remdesivir vs. interferon 0.79 [0.63; 1.00]0.79 [0.63;1.00]remdesivir vs. interferon 0.79 [0.63; 1.00]remdesivir vs. lopinavir/ritonavir 0.90 [0.75; 1.08]0.90 [0.75;1.08]remdesivir vs. lopinavir/ritonavir 0.90 [0.75; 1.08]remdesivir vs. Vitamin D 0.87 [0.31; 2.47]0.87 [0.31;2.47]remdesivir vs. Vitamin D 0.87 [0.31; 2.47]Vitamin D vs. anti-interleukin-6 1.31 [0.46; 3.75]1.31 [0.46;3.75]Vitamin D vs. anti-interleukin-6 1.31 [0.46; 3.75]Vitamin D vs. baricitinib plus remdesivir 1.76 [0.55; 5.63]1.76 [0.55;5.63]Vitamin D vs. baricitinib plus remdesivir 1.76 [0.55; 5.63]Vitamin D vs. colchicine 3.38 [0.38; 30.33]3.38 [0.38;30.33]Vitamin D vs. colchicine 3.38 [0.38; 30.33]Vitamin D vs. control 1.05 [0.37; 2.93]1.05 [0.37;2.93]Vitamin D vs. control 1.05 [0.37; 2.93]Vitamin D vs. convalescent plasma treatment 1.32 [0.42; 4.13]1.32 [0.42;4.13]Vitamin D vs. convalescent plasma treatment 1.32 [0.42; 4.13]Vitamin D vs. corticosteroids 1.19 [0.42; 3.34]1.19 [0.42;3.34]Vitamin D vs. corticosteroids 1.19 [0.42; 3.34]Vitamin D vs. hydroxychloroquine 0.98 [0.35; 2.77]0.98 [0.35;2.77]Vitamin D vs. hydroxychloroquine 0.98 [0.35; 2.77]Vitamin D vs. interferon 0.91 [0.32; 2.58]0.91 [0.32;2.58]Vitamin D vs. interferon 0.91 [0.32; 2.58]Vitamin D vs. lopinavir/ritonavir 1.03 [0.37; 2.91]1.03 [0.37;2.91]Vitamin D vs. lopinavir/ritonavir 1.03 [0.37; 2.91]Vitamin D vs. remdesivir 1.15 [0.41; 3.24]1.15 [0.41;3.24]Vitamin D vs. remdesivir 1.15 [0.41; 3.24]corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferonanti-interleukin-6lopinavir/ritonavircolchicineVitamin Dbaricitinib plus remdesivircontroldirect evidencenetwork meta-analysis

Click on treatment name to display related network evidence

T vs. C corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferonanti-interleukin-6lopinavir/ritonavircolchicineVitamin Dbaricitinib plus remdesivircontrol
corticosteroids---0.97
0.82; 1.14
0.83
0.73; 0.94
1.11
0.67; 1.83
0.76
0.62; 0.94
1.10
0.86; 1.40
0.87
0.76; 1.00
2.85
0.41; 19.80
0.84
0.30; 2.37
1.49
0.87; 2.55
0.88
0.81; 0.96
remdesivir1.04
0.87; 1.22
---0.86
0.72; 1.02
1.15
0.69; 1.92
0.79
0.63; 1.00
1.14
0.87; 1.49
0.90
0.75; 1.08
2.94
0.42; 20.56
0.87
0.31; 2.47
1.54
0.92; 2.57
0.91
0.79; 1.05
hydroxychloroquine1.21
1.06; 1.37
1.17
0.98; 1.39
---1.34
0.81; 2.21
0.92
0.75; 1.14
1.33
1.04; 1.70
1.05
0.90; 1.22
3.43
0.49; 23.91
1.02
0.36; 2.86
1.79
1.04; 3.09
1.06
0.96; 1.18
convalescent plasma treatment0.90
0.55; 1.48
0.87
0.52; 1.45
0.75
0.45; 1.23
---0.69
0.41; 1.16
0.99
0.58; 1.70
0.78
0.47; 1.29
2.56
0.35; 18.91
0.76
0.24; 2.37
1.34
0.65; 2.76
0.79
0.49; 1.29
interferon1.31
1.07; 1.60
1.26
1.00; 1.59
1.08
0.88; 1.34
1.45
0.86; 2.45
---1.44
1.08; 1.92
1.14
0.92; 1.41
3.72
0.53; 26.07
1.10
0.39; 3.13
1.94
1.11; 3.42
1.15
0.96; 1.38
anti-interleukin-60.91
0.71; 1.16
0.88
0.67; 1.15
0.75
0.59; 0.96
1.01
0.59; 1.73
0.69
0.52; 0.93
---0.79
0.62; 1.02
2.59
0.37; 18.20
0.77
0.27; 2.20
1.35
0.76; 2.41
0.80
0.64; 1.00
lopinavir/ritonavir1.15
1.00; 1.32
1.11
0.93; 1.33
0.95
0.82; 1.11
1.28
0.77; 2.11
0.88
0.71; 1.09
1.26
0.98; 1.63
---3.27
0.47; 22.79
0.97
0.34; 2.73
1.71
0.99; 2.94
1.01
0.91; 1.13
colchicine0.35
0.05; 2.45
0.34
0.05; 2.37
0.29
0.04; 2.03
0.39
0.05; 2.88
0.27
0.04; 1.88
0.39
0.05; 2.72
0.31
0.04; 2.13
---0.30
0.03; 2.66
0.52
0.07; 3.90
0.31
0.04; 2.15
Vitamin D1.19
0.42; 3.34
1.15
0.41; 3.24
0.98
0.35; 2.77
1.32
0.42; 4.13
0.91
0.32; 2.58
1.31
0.46; 3.75
1.03
0.37; 2.91
3.38
0.38; 30.33
---1.76
0.55; 5.63
1.05
0.37; 2.93
baricitinib plus remdesivir0.67
0.39; 1.16
0.65
0.39; 1.09
0.56
0.32; 0.96
0.75
0.36; 1.54
0.51
0.29; 0.90
0.74
0.41; 1.32
0.59
0.34; 1.01
1.91
0.26; 14.29
0.57
0.18; 1.81
---0.59
0.35; 1.01
control1.14
1.04; 1.24
1.10
0.95; 1.27
0.94
0.85; 1.04
1.26
0.77; 2.06
0.87
0.72; 1.04
1.25
1.00; 1.57
0.99
0.89; 1.10
3.23
0.46; 22.43
0.96
0.34; 2.68
1.69
0.99; 2.88
---

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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