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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19

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Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Interactive explorer of NMA results

3CODEX (Tomazini), 2020 REMAP-CAP, fixed 7-day course, 2020 REMAP-CAP, shock-dependent course, 20201COALITION II (Furtado), 20201CAP-China (Wang et al.), 20202Li, 2015 PlasmAr, 20204COVACTA (Rosas), 2020 BACC Bay Tocilizumab Trial, 2020 REMAP-CAP tocilizumab, 2021 REMAP-CAP sarilumab, 20211Cao B, 20201Murai, 2020anti-interleukin-6 vs. control 0.76 [0.59; 0.97]0.76 [0.59;0.97]anti-interleukin-6 vs. control 0.76 [0.59; 0.97]anti-interleukin-6 vs. convalescent plasma treatment 0.95 [0.51; 1.75]0.95 [0.51;1.75]anti-interleukin-6 vs. convalescent plasma treatment 0.95 [0.51; 1.75]anti-interleukin-6 vs. corticosteroids 0.79 [0.57; 1.09]0.79 [0.57;1.09]anti-interleukin-6 vs. corticosteroids 0.79 [0.57; 1.09]anti-interleukin-6 vs. hydroxychloroquine 0.85 [0.54; 1.33]0.85 [0.54;1.33]anti-interleukin-6 vs. hydroxychloroquine 0.85 [0.54; 1.33]anti-interleukin-6 vs. lopinavir/ritonavir 1.06 [0.52; 2.18]1.06 [0.52;2.18]anti-interleukin-6 vs. lopinavir/ritonavir 1.06 [0.52; 2.18]anti-interleukin-6 vs. remdesivir 0.69 [0.30; 1.59]0.69 [0.30;1.59]anti-interleukin-6 vs. remdesivir 0.69 [0.30; 1.59]anti-interleukin-6 vs. Vitamin D 0.56 [0.18; 1.71]0.56 [0.18;1.71]anti-interleukin-6 vs. Vitamin D 0.56 [0.18; 1.71]control vs. anti-interleukin-6 1.32 [1.03; 1.68]1.32 [1.03;1.68]control vs. anti-interleukin-6 1.32 [1.03; 1.68]control vs. convalescent plasma treatment 1.25 [0.71; 2.19]1.25 [0.71;2.19]control vs. convalescent plasma treatment 1.25 [0.71; 2.19]control vs. corticosteroids 1.04 [0.84; 1.29]1.04 [0.84;1.29]control vs. corticosteroids 1.04 [0.84; 1.29]control vs. hydroxychloroquine 1.12 [0.77; 1.63]1.12 [0.77;1.63]control vs. hydroxychloroquine 1.12 [0.77; 1.63]control vs. lopinavir/ritonavir 1.40 [0.71; 2.76]1.40 [0.71;2.76]control vs. lopinavir/ritonavir 1.40 [0.71; 2.76]control vs. remdesivir 0.91 [0.41; 2.03]0.91 [0.41;2.03]control vs. remdesivir 0.91 [0.41; 2.03]control vs. Vitamin D 0.74 [0.25; 2.19]0.74 [0.25;2.19]control vs. Vitamin D 0.74 [0.25; 2.19]convalescent plasma treatment vs. anti-interleukin-6 1.06 [0.57; 1.96]1.06 [0.57;1.96]convalescent plasma treatment vs. anti-interleukin-6 1.06 [0.57; 1.96]convalescent plasma treatment vs. control 0.80 [0.46; 1.41]0.80 [0.46;1.41]convalescent plasma treatment vs. control 0.80 [0.46; 1.41]convalescent plasma treatment vs. corticosteroids 0.83 [0.45; 1.52]0.83 [0.45;1.52]convalescent plasma treatment vs. corticosteroids 0.83 [0.45; 1.52]convalescent plasma treatment vs. hydroxychloroquine 0.90 [0.45; 1.77]0.90 [0.45;1.77]convalescent plasma treatment vs. hydroxychloroquine 0.90 [0.45; 1.77]convalescent plasma treatment vs. lopinavir/ritonavir 1.13 [0.47; 2.71]1.13 [0.47;2.71]convalescent plasma treatment vs. lopinavir/ritonavir 1.13 [0.47; 2.71]convalescent plasma treatment vs. remdesivir 0.73 [0.27; 1.94]0.73 [0.27;1.94]convalescent plasma treatment vs. remdesivir 0.73 [0.27; 1.94]convalescent plasma treatment vs. Vitamin D 0.59 [0.17; 2.02]0.59 [0.17;2.02]convalescent plasma treatment vs. Vitamin D 0.59 [0.17; 2.02]corticosteroids vs. anti-interleukin-6 1.27 [0.92; 1.76]1.27 [0.92;1.76]corticosteroids vs. anti-interleukin-6 1.27 [0.92; 1.76]corticosteroids vs. control 0.96 [0.78; 1.20]0.96 [0.78;1.20]corticosteroids vs. control 0.96 [0.78; 1.20]corticosteroids vs. convalescent plasma treatment 1.20 [0.66; 2.20]1.20 [0.66;2.20]corticosteroids vs. convalescent plasma treatment 1.20 [0.66; 2.20]corticosteroids vs. hydroxychloroquine 1.08 [0.79; 1.47]1.08 [0.79;1.47]corticosteroids vs. hydroxychloroquine 1.08 [0.79; 1.47]corticosteroids vs. lopinavir/ritonavir 1.35 [0.67; 2.75]1.35 [0.67;2.75]corticosteroids vs. lopinavir/ritonavir 1.35 [0.67; 2.75]corticosteroids vs. remdesivir 0.88 [0.38; 2.01]0.88 [0.38;2.01]corticosteroids vs. remdesivir 0.88 [0.38; 2.01]corticosteroids vs. Vitamin D 0.71 [0.23; 2.16]0.71 [0.23;2.16]corticosteroids vs. Vitamin D 0.71 [0.23; 2.16]hydroxychloroquine vs. anti-interleukin-6 1.18 [0.75; 1.85]1.18 [0.75;1.85]hydroxychloroquine vs. anti-interleukin-6 1.18 [0.75; 1.85]hydroxychloroquine vs. control 0.89 [0.61; 1.30]0.89 [0.61;1.30]hydroxychloroquine vs. control 0.89 [0.61; 1.30]hydroxychloroquine vs. convalescent plasma treatment 1.11 [0.56; 2.20]1.11 [0.56;2.20]hydroxychloroquine vs. convalescent plasma treatment 1.11 [0.56; 2.20]hydroxychloroquine vs. corticosteroids 0.93 [0.68; 1.26]0.93 [0.68;1.26]hydroxychloroquine vs. corticosteroids 0.93 [0.68; 1.26]hydroxychloroquine vs. lopinavir/ritonavir 1.25 [0.58; 2.72]1.25 [0.58;2.72]hydroxychloroquine vs. lopinavir/ritonavir 1.25 [0.58; 2.72]hydroxychloroquine vs. remdesivir 0.81 [0.33; 1.97]0.81 [0.33;1.97]hydroxychloroquine vs. remdesivir 0.81 [0.33; 1.97]hydroxychloroquine vs. Vitamin D 0.66 [0.21; 2.09]0.66 [0.21;2.09]hydroxychloroquine vs. Vitamin D 0.66 [0.21; 2.09]lopinavir/ritonavir vs. anti-interleukin-6 0.94 [0.46; 1.93]0.94 [0.46;1.93]lopinavir/ritonavir vs. anti-interleukin-6 0.94 [0.46; 1.93]lopinavir/ritonavir vs. control 0.71 [0.36; 1.40]0.71 [0.36;1.40]lopinavir/ritonavir vs. control 0.71 [0.36; 1.40]lopinavir/ritonavir vs. convalescent plasma treatment 0.89 [0.37; 2.14]0.89 [0.37;2.14]lopinavir/ritonavir vs. convalescent plasma treatment 0.89 [0.37; 2.14]lopinavir/ritonavir vs. corticosteroids 0.74 [0.36; 1.50]0.74 [0.36;1.50]lopinavir/ritonavir vs. corticosteroids 0.74 [0.36; 1.50]lopinavir/ritonavir vs. hydroxychloroquine 0.80 [0.37; 1.73]0.80 [0.37;1.73]lopinavir/ritonavir vs. hydroxychloroquine 0.80 [0.37; 1.73]lopinavir/ritonavir vs. remdesivir 0.65 [0.23; 1.85]0.65 [0.23;1.85]lopinavir/ritonavir vs. remdesivir 0.65 [0.23; 1.85]lopinavir/ritonavir vs. Vitamin D 0.52 [0.15; 1.89]0.52 [0.15;1.89]lopinavir/ritonavir vs. Vitamin D 0.52 [0.15; 1.89]remdesivir vs. anti-interleukin-6 1.45 [0.63; 3.36]1.45 [0.63;3.36]remdesivir vs. anti-interleukin-6 1.45 [0.63; 3.36]remdesivir vs. control 1.10 [0.49; 2.45]1.10 [0.49;2.45]remdesivir vs. control 1.10 [0.49; 2.45]remdesivir vs. convalescent plasma treatment 1.37 [0.51; 3.66]1.37 [0.51;3.66]remdesivir vs. convalescent plasma treatment 1.37 [0.51; 3.66]remdesivir vs. corticosteroids 1.14 [0.50; 2.62]1.14 [0.50;2.62]remdesivir vs. corticosteroids 1.14 [0.50; 2.62]remdesivir vs. hydroxychloroquine 1.23 [0.51; 2.99]1.23 [0.51;2.99]remdesivir vs. hydroxychloroquine 1.23 [0.51; 2.99]remdesivir vs. lopinavir/ritonavir 1.54 [0.54; 4.40]1.54 [0.54;4.40]remdesivir vs. lopinavir/ritonavir 1.54 [0.54; 4.40]remdesivir vs. Vitamin D 0.81 [0.21; 3.14]0.81 [0.21;3.14]remdesivir vs. Vitamin D 0.81 [0.21; 3.14]Vitamin D vs. anti-interleukin-6 1.79 [0.59; 5.47]1.79 [0.59;5.47]Vitamin D vs. anti-interleukin-6 1.79 [0.59; 5.47]Vitamin D vs. control 1.36 [0.46; 4.04]1.36 [0.46;4.04]Vitamin D vs. control 1.36 [0.46; 4.04]Vitamin D vs. convalescent plasma treatment 1.69 [0.50; 5.78]1.69 [0.50;5.78]Vitamin D vs. convalescent plasma treatment 1.69 [0.50; 5.78]Vitamin D vs. corticosteroids 1.41 [0.46; 4.27]1.41 [0.46;4.27]Vitamin D vs. corticosteroids 1.41 [0.46; 4.27]Vitamin D vs. hydroxychloroquine 1.52 [0.48; 4.82]1.52 [0.48;4.82]Vitamin D vs. hydroxychloroquine 1.52 [0.48; 4.82]Vitamin D vs. lopinavir/ritonavir 1.90 [0.53; 6.86]1.90 [0.53;6.86]Vitamin D vs. lopinavir/ritonavir 1.90 [0.53; 6.86]Vitamin D vs. remdesivir 1.23 [0.32; 4.78]1.23 [0.32;4.78]Vitamin D vs. remdesivir 1.23 [0.32; 4.78]corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferonanti-interleukin-6lopinavir/ritonavircolchicineVitamin Dbaricitinib plus remdesivircontroldirect evidencenetwork meta-analysis

Click on treatment name to display related network evidence

T vs. C corticosteroidsremdesivirhydroxychloroquineconvalescent plasma treatmentinterferonanti-interleukin-6lopinavir/ritonavircolchicineVitamin Dbaricitinib plus remdesivircontrol
corticosteroids---0.88
0.38; 2.01
1.08
0.79; 1.47
1.20
0.66; 2.20
NA1.27
0.92; 1.76
1.35
0.67; 2.75
NA0.71
0.23; 2.16
NA0.96
0.78; 1.20
remdesivir1.14
0.50; 2.62
---1.23
0.51; 2.99
1.37
0.51; 3.66
NA1.45
0.63; 3.36
1.54
0.54; 4.40
NA0.81
0.21; 3.14
NA1.10
0.49; 2.45
hydroxychloroquine0.93
0.68; 1.26
0.81
0.33; 1.97
---1.11
0.56; 2.20
NA1.18
0.75; 1.85
1.25
0.58; 2.72
NA0.66
0.21; 2.09
NA0.89
0.61; 1.30
convalescent plasma treatment0.83
0.45; 1.52
0.73
0.27; 1.94
0.90
0.45; 1.77
---NA1.06
0.57; 1.96
1.13
0.47; 2.71
NA0.59
0.17; 2.02
NA0.80
0.46; 1.41
interferonNANANANA---NANANANANANA
anti-interleukin-60.79
0.57; 1.09
0.69
0.30; 1.59
0.85
0.54; 1.33
0.95
0.51; 1.75
NA---1.06
0.52; 2.18
NA0.56
0.18; 1.71
NA0.76
0.59; 0.97
lopinavir/ritonavir0.74
0.36; 1.50
0.65
0.23; 1.85
0.80
0.37; 1.73
0.89
0.37; 2.14
NA0.94
0.46; 1.93
---NA0.52
0.15; 1.89
NA0.71
0.36; 1.40
colchicineNANANANANANANA---NANANA
Vitamin D1.41
0.46; 4.27
1.23
0.32; 4.78
1.52
0.48; 4.82
1.69
0.50; 5.78
NA1.79
0.59; 5.47
1.90
0.53; 6.86
NA---NA1.36
0.46; 4.04
baricitinib plus remdesivirNANANANANANANANANA---NA
control1.04
0.84; 1.29
0.91
0.41; 2.03
1.12
0.77; 1.63
1.25
0.71; 2.19
NA1.32
1.03; 1.68
1.40
0.71; 2.76
NA0.74
0.25; 2.19
NA---

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N) and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

   

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