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meta|Evidence - COVID-19

Live meta-analysis and evidence synthesis of therapies for COVID19  

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Treament Trials
Demonstrated or suggested benefit Inconclusive results Uncertain results Safety results
0- - - -
2

statistically conclusive 38 % increase in clinical improvement

suggested 57 % increase in clinical improvement (14-day)

suggested 81 % increase in clinical improvement (28-day)

suggested 30 % increase in clinical improvement (7-day)

suggested 47 % decrease in serious adverse events

inconclusive results for: deaths; deaths (time to event analysis only); clinical improvement (time to event analysis only); ventilation; time to recovery; adverse events--
5 noneinconclusive results for: deaths; clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); radiologic improvement (7-day); viral clearance ; viral clearance (time to event analysis only); adverse events--
2

statistically conclusive 48 % decrease in clinical deterioration

inconclusive results for: death or transfer to ICU; deaths; ventilation; viral clearance by day 7; ICU admission--
3 noneinconclusive results for: deaths; clinical deterioration; hospital discharge; hospitalization; viral clearance (time to event analysis only); viral clearance by day 7; serious adverse events; adverse events--
3

suggested 45 % decrease in clinical deterioration

statistically conclusive 44 % decrease in death or ventilation

inconclusive results for: deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (time to event analysis only); hospital discharge--
0- - - -
0- - - -
0- - - -
0- - - -

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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