meta
|
evidence
COVID-19
Living systematic review and meta-analysis
adjuvant therapies
anti-inflammatoty and immuno-therapy
antiandrogenic
antiviral and associated therapy
control
Drugs for acid related disorders
miscellaneous
2-deoxy-D-glucose (2-DG)
acetylcysteine
alpha lipoic acid
anti-CK2
Aspirin
aviptadil
BLD-2660 (calpain inhibitor)
calcium channel blocker
camostat mesilate
Cannabidiol
continuous positive airway pressure (CPAP)
cytokine adsorption
diammonium glycyrrhizinate
dipyridamol
dornase alfa
expectorants and mucolytics
honey
kinin-kallikrein inhibitors
melatonin
mouthrise and gargling agents
mouthrinses
N-Acetylcysteine
nasal spray
nasal spray containing Iota-Carrageenan
natural killer (NK) cells
nicotin
nigella sativa oil
nitric oxide (gas Inhalation or releasing solution)
omega-3 Polyunsaturated Fatty Acids
ozonated autohemotherapy
plasma exchange
povidone-iodine
previfenon (EGCG)
prostacyclin
PUL-042 inhalation solution
pyridostigmine
radiotherapy
sabizabulin
sildenafil
triiodothyronine (T3)
Oral antidiabetic drugs
Renin-angiotensin-system-acting agents
vaccines
Vitamins
COVID 19 hospitalized
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
COVID 19 outpatients
COVID-19 (hospitalized or not)
COVID-19 prophylaxis (children)
COVID-19 prophylaxis (excluding children)
infections other than COVID-19
Long COVID-19
preventing respiratory virus transmission
secondary prevention
Meta-analysis results for all treatments
Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE).
method
Treament
Trials
Summary
Endpoints
14-days deaths
death D28
death or transfer to ICU
deaths
deaths (time to event analysis only)
clinical improvement
clinical improvement (time to event analysis only)
death or ventilation
hospital discharge
mechanical ventilation
mechanical ventilation (time to event analysis only)
ICU admission
recovery
serious adverse events
adverse events
core analysis (OBS if no RCT)
RCTs only
all (RCT+OBS)
clinical deterioration
clinical improvement
deaths
viral clearance
camostat mesilate
1
-
1.14
[0.83; 1.57], 1 RCT, I2=0%
inconclusive result
0.70
[0.20; 2.49], 1 RCT, I2=0%
inconclusive result
-
2-deoxy-D-glucose (2-DG)
0
-
-
-
-
acetylcysteine
0
-
-
-
-
alpha lipoic acid
0
-
-
-
-
anti-CK2
0
-
-
-
-
Aspirin
0
-
-
-
-
aviptadil
0
-
-
-
-
BLD-2660 (calpain inhibitor)
0
-
-
-
-
calcium channel blocker
0
-
-
-
-
Cannabidiol
0
-
-
-
-
continuous positive airway pressure (CPAP)
0
-
-
-
-
cytokine adsorption
0
-
-
-
-
diammonium glycyrrhizinate
0
-
-
-
-
dipyridamol
0
-
-
-
-
dornase alfa
0
-
-
-
-
expectorants and mucolytics
0
-
-
-
-
honey
0
-
-
-
-
kinin-kallikrein inhibitors
0
-
-
-
-
melatonin
0
-
-
-
-
mouthrise and gargling agents
0
-
-
-
-
N-Acetylcysteine
0
-
-
-
-
nasal spray
0
-
-
-
-
natural killer (NK) cells
0
-
-
-
-
nicotin
0
-
-
-
-
nigella sativa oil
0
-
-
-
-
nitric oxide (gas Inhalation or releasing solution)
0
-
-
-
-
omega-3 Polyunsaturated Fatty Acids
0
-
-
-
-
ozonated autohemotherapy
0
-
-
-
-
plasma exchange
0
-
-
-
-
povidone-iodine
0
-
-
-
-
previfenon (EGCG)
0
-
-
-
-
prostacyclin
0
-
-
-
-
PUL-042 inhalation solution
0
-
-
-
-
pyridostigmine
0
-
-
-
-
radiotherapy
0
-
-
-
-
sabizabulin
0
-
-
-
-
sildenafil
0
-
-
-
-
triiodothyronine (T3)
0
-
-
-
-