Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Gonzalez (HCQ)
  NCT04391127		 RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
33/37 inconclusive
    HYCOVID
          NCT04325893    		 RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
    		124/123 inconclusive
    • inconclusive 12 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
    ORCHID
          NCT04332991    		 RCThydroxychloroquineplaceboCOVID 19 hospitalizedlow
    		242/237 inconclusive
    • inconclusive 2 % increase in clinical improvement,clinical improvement (14-day) (PE) with a high degree of certainty due to low risk of bias
    TEACH
          NCT04369742    		 RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
    		67/61 inconclusive
    • inconclusive 80 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
    • inconclusive 16 % increase in adverse events (PE) with a moderate degree of certainty due to some concern in risk of bias

    COVID-19 mild to moderate meta-analysis

    NCT04342650
          NCT04342650    		 RCTchloroquineplaceboCOVID-19 mild to moderateNA
    		-/- inconclusive

      COVID-19 severe or critically meta-analysis

      HYDRA (Hernandez-Cardenas)
              NCT04315896      		 RCThydroxychloroquineplaceboCOVID-19 severe or criticallysome concern
      		106/108 inconclusive
      • inconclusive 20 % decrease in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

       

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