Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 severe or critically meta-analysis

Hamed RCTtocilizumab standard of careCOVID-19 severe or criticallyhigh
26/23 inconclusive
  • inconclusive 83 % increase in deaths (PE) but with a low degree of certainty due to high risk of bias
  • inconclusive 2.2-fold increase in ICU admission (PE) but with a low degree of certainty due to high risk of bias
REMAP-CAP (tocilizumab)
  NCT02735707		 RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
353/402 conclusif
  • suggested 30 % decrease in deaths with a moderate degree of certainty due to some concern in risk of bias
  • demonstrated 64 % increase in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
Rosas (REMDACTA)
  NCT04409262		 RCTtocilizumab placeboCOVID-19 severe or criticallysome concern
434/215 inconclusive
  • inconclusive 3 % decrease in hospital discharge (PE) with a moderate degree of certainty due to some concern in risk of bias
Talaschian
  IRCT20081027001411N4		 RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
20/20 inconclusive
    Veiga
          NCT04403685    		 RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
    		65/64 safety concern
    • safety concern with 1.7-fold increase in deaths,death D28 (not statistically significant)
    • inconclusive 54 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
    CORIMUNO-TOCI-1 (Group 1)
          NCT04331808    		 RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
    		64/67 inconclusive
      CORIMUNO-TOCI-ICU (Group 2)
              NCT04331808      		 RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
      		49/43 inconclusive
        COVACTA (Rosas)
                  NCT04320615        		 RCTtocilizumab placeboCOVID-19 severe or criticallysome concern
        		301/151 suggested
        • inconclusive 19 % increase in clinical improvement,clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
        NCT04377750 (HMO-0224-20) unpublished
                  NCT04377750        		 RCTtocilizumab placeboCOVID-19 severe or criticallyhigh
        		37/17 inconclusive
          6 studies excluded by filtering options (0 RCT / 6 OBS)

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

           

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