Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

COLCOVID
  NCT04328480		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
640/639 inconclusive
  • inconclusive 17 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
Horby
  NCT04381936		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
5610/5730 inconclusive
    RECOVERY (colchicine)
          NCT04381936    		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
    		5610/5730 inconclusive
    • inconclusive 1 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
    GRECCO-19
          NCT04326790    		 RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
    		55/50 suggested
    • suggested 89 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias

    COVID-19 mild to moderate meta-analysis

    COL-COVID (Pascual-Figal)
          NCT04350320    		 RCTcolchicinestandard of careCOVID-19 mild to moderatesome concern
    		52/51 inconclusive
      Rashad (CLARI vs SoC) RCTclarithromycinestandard of careCOVID-19 mild to moderatesome concern
      		99/99 suggested
      • suggested 1.9-fold increase in radiologic improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias

      COVID-19 severe or critically meta-analysis

      Shu
              ChiCTR2000031494      		 RCTstem cellsstandard of careCOVID-19 severe or criticallysome concern
      		12/29 suggested
      • inconclusive 73 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
      • suggested 9.3-fold increase in clinical improvement,clinical improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
      • suggested 5.7-fold increase in clinical improvement (7-day) with a moderate degree of certainty due to some concern in risk of bias
      3 studies excluded by filtering options (0 RCT / 3 OBS)

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

       

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