Study study type PathologyT1T0Patientssample sizesROB Results

es-BC - TNBC - NA - all population breast cancer - triple negative es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA) es-BC - TNBC - NA - all population

versus carboplatin plus nab-paclitaxel
atezolizumab plus carboplatin plus nab-paclitaxel
NeoTRIPaPDLA unpublished
  NCT02620280
RCTes-BC - TNBC - NA - all populationatezolizumab plus carboplatine plus nab-paclitaxelcarboplatine plus nab-paclitaxelNeoadjuvant Therapy in TRIPle Negative Breast Cancer (early or locally advanced)88 / 86NA
inconclusive
    no statistically significant result
versus placebo
durvalumab alone
GeparNuevo, 2019
  NCT02685059
RCTes-BC - TNBC - NA - all populationdurvalumab followed by nab-paclitaxelplacebo followed by nab-paclitaxelPatients with previously untreated uni- or bilateral primary, non-metastatic invasive TNBC with a tumour of at least 2 cm (cT2-cT4a-d) treated as neoadjuvant88 / 86some concern
suggested
  • suggested 76 % decrease in deaths (OS) (extension)
  • inconclusive 45 % increase in pCR (PE)
pembrolizumab alone
KEYNOTE-522, 2020
  NCT03036488
RCTes-BC - TNBC - NA - all populationpembrolizumabplacebopreviously previously untreated, nonmetastatic disease, stage II or stage III, triple-negative breast cancer treated with paclitaxel and carboplatin, treated for neoadjuvant phase and an adjuvant phase;784 / 390low
conclusif
  • demonstrated 12.6-fold increase in pCR (PE)
  • suggested 37 % decrease in events or deaths (EFS) (PE)
versus placebo plus SoC
atezolizumab plus nab-paclitxel followed by doxorubicin plus cyclophosphamide
IMpassion-031 (all population), 2020
  NCT03197935
RCTes-BC - TNBC - NA - all populationAtezolizumab plus nab-paclitaxel followed by doxorubicin and cyclophosphamide with filgrastim or pegfilgrastim supportplacebo plus nab-paclitaxel followed by doxorubicin and cyclophosphamide with filgrastim or pegfilgrastim supportneoadjuvant setting in participants with early stage (stage II-III) triple negative breast cancer165 / 168low
conclusif
  • demonstrated 95 % increase in pCR (PE)

es-BC - TNBC - NA - PDL1 positive breast cancer - triple negative es-BC - Triple negatif (TNBC) - (neo)adjuvant (NA) es-BC - TNBC - NA - PDL1 positive

versus placebo plus SoC
atezolizumab plus nab-paclitxel followed by doxorubicin plus cyclophosphamide
IMpassion-031 (PDL1>1%), 2020
  NCT03197935
RCTes-BC - TNBC - NA - PDL1 positiveAtezolizumab plus nab-paclitaxel followed by doxorubicin and cyclophosphamide with filgrastim or pegfilgrastim supportplacebo plus nab-paclitaxel followed by doxorubicin and cyclophosphamide with filgrastim or pegfilgrastim supportneoadjuvant setting in participants with early stage (stage II III) triple negative breast cancer with PDL1 >1%78 / 76low
suggested
  • suggested 1.2-fold increase in pCR (PE)