published meta-analysis   sensitivity analysis   studies

anti-inflammatoty and immuno-therapy in COVID-19 mild to moderate - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsCAN-COVID, 2020 0.67 [0.30; 1.50] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] CORIMUNO-ANA-1, 2021 0.91 [0.38; 2.19] Pandit, 2021 0.95 [0.02; 50.33] PLACID, 2020 1.04 [0.66; 1.63] Shashi Bhushan, 2021 4.39 [0.20; 98.33] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] 0.78[0.60; 1.02]CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Pandit, 2021, PLACID, 2020, Shashi Bhushan, 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 202170%2,612moderatenot evaluable death or transfer to ICUdetailed resultsPLACID, 2020 1.07 [0.73; 1.57] 1.07[0.73; 1.57]PLACID, 202010%464NAnot evaluable deathsdetailed resultsCAN-COVID, 2020 0.67 [0.30; 1.50] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] CORIMUNO-ANA-1, 2021 0.97 [0.46; 2.04] Fu, 2020 1.00 [0.02; 51.66] Libster, 2020 0.50 [0.09; 2.71] LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] Lopes MIF, 2020 1.06 [0.02; 56.61] Murugesan, 2022 1.00 [0.02; 51.41] Pandit, 2021 0.95 [0.02; 50.33] PLACID, 2020 1.04 [0.66; 1.63] SAVE-MORE, 2021 0.45 [0.20; 0.99] Shashi Bhushan, 2021 4.39 [0.20; 98.33] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] 0.74[0.59; 0.92]CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Fu, 2020, Libster, 2020, LIVE-AIR (Temesgen), 2021, Lopes MIF, 2020, Murugesan, 2022, Pandit, 2021, PLACID, 2020, SAVE-MORE, 2021, Shashi Bhushan, 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021130%4,060moderatelow deaths (time to event analysis only)detailed resultsLIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] 0.70[0.40; 1.21]LIVE-AIR (Temesgen), 202110%479NAnot evaluable clinical deteriorationdetailed resultsCOL-COVID (Pascual-Figal), 2021 0.38 [0.09; 1.58] CORIMUNO-ANA-1, 2021 0.89 [0.42; 1.92] Libster, 2020 0.52 [0.29; 0.94] PLACID, 2020 1.04 [0.54; 1.99] SAVE-MORE, 2021 0.36 [0.26; 0.50] 0.58[0.36; 0.94]COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Libster, 2020, PLACID, 2020, SAVE-MORE, 2021564%841moderatenot evaluable clinical improvementdetailed resultsCAN-COVID, 2020 1.39 [0.76; 2.54] Shashi Bhushan, 2021 0.68 [0.21; 2.20] 1.17[0.64; 2.13]CAN-COVID, 2020, Shashi Bhushan, 2021212%688moderatenot evaluable clinical improvement (14-day)detailed resultsPandit, 2021 8.77 [0.94; 81.67] Shashi Bhushan, 2021 0.68 [0.21; 2.20] 2.03[0.17; 24.32]Pandit, 2021, Shashi Bhushan, 2021275%281moderatenot evaluable clinical improvement (7-day)detailed resultsShashi Bhushan, 2021 1.91 [1.03; 3.53] 1.91[1.03; 3.53]Shashi Bhushan, 202110%222NAnot evaluable death or ventilationdetailed resultsCORIMUNO-ANA-1, 2021 0.97 [0.62; 1.52] LIVE-AIR (Temesgen), 2021 0.65 [0.43; 0.98] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.66 [0.46; 0.94] 0.73[0.57; 0.93]CORIMUNO-ANA-1, 2021, LIVE-AIR (Temesgen), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 202139%1,313moderatenot evaluable hospital dischargedetailed resultsSomersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 1.48 [1.05; 2.09] 1.48[1.05; 2.09]Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 202110%1,197NAnot evaluable hospitalizationdetailed resultsJagannathan, 2020 1.00 [0.14; 7.34] 1.00[0.14; 7.34]Jagannathan, 202010%120NAnot evaluable mechanical ventilationdetailed resultsCOL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] PLACID, 2020 0.99 [0.54; 1.81] SAVE-MORE, 2021 0.47 [0.03; 7.48] 0.91[0.51; 1.63]COL-COVID (Pascual-Figal), 2021, PLACID, 2020, SAVE-MORE, 202130%1,148seriousnot evaluable radiologic improvement (14-day)detailed resultsRashad (CLARI vs SoC), 2021 2.87 [1.56; 5.28] 2.87[1.56; 5.28]Rashad (CLARI vs SoC), 202110%198NAnot evaluable viral clearance detailed resultsJagannathan, 2020 0.81 [0.56; 1.18] Pandit, 2021 2.33 [0.55; 9.83] Shashi Bhushan, 2021 2.77 [1.44; 5.32] 1.61[0.61; 4.25]Jagannathan, 2020, Pandit, 2021, Shashi Bhushan, 2021382%401moderatenot evaluable viral clearance (time to event analysis only)detailed resultsJagannathan, 2020 0.81 [0.56; 1.18] 0.81[0.56; 1.18]Jagannathan, 202010%120NAnot evaluable viral clearance by day 14detailed resultsPandit, 2021 10.23 [1.12; 93.35] Shashi Bhushan, 2021 0.00 [0.00; 0.01] 0.18[0.00; 435.69]Pandit, 2021, Shashi Bhushan, 2021298%1,359moderatenot evaluable viral clearance by day 7detailed resultsPandit, 2021 2.33 [0.55; 9.83] PLACID, 2020 1.20 [1.00; 1.44] Shashi Bhushan, 2021 2.77 [1.44; 5.32] 1.78[0.91; 3.47]Pandit, 2021, PLACID, 2020, Shashi Bhushan, 2021369%623moderatenot evaluable ICU admissiondetailed resultsCOL-COVID (Pascual-Figal), 2021 0.47 [0.08; 2.69] Libster, 2020 0.33 [0.07; 1.58] 0.39[0.12; 1.24]COL-COVID (Pascual-Figal), 2021, Libster, 202020%263lownot evaluable serious adverse eventsdetailed resultsCAN-COVID, 2020 0.73 [0.45; 1.19] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] Jagannathan, 2020 1.00 [0.14; 7.34] Pandit, 2021 0.95 [0.02; 50.33] 0.73[0.46; 1.16]CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, Jagannathan, 2020, Pandit, 202140%710moderatenot evaluable adverse eventsdetailed resultsCOL-COVID (Pascual-Figal), 2021 1.72 [0.73; 4.08] Jagannathan, 2020 1.33 [0.63; 2.78] Pandit, 2021 1.68 [0.47; 5.97] 1.51[0.91; 2.52]COL-COVID (Pascual-Figal), 2021, Jagannathan, 2020, Pandit, 202130%262moderatenot evaluable0.05.01.0relative treatment effectwww.metaEvidence.org2024-04-26 18:30 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 90 - treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525 - roots T: 290