published meta-analysis   sensitivity analysis   studies

anti-inflammatoty and immuno-therapy in COVID 19 hospitalized - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsBalcells, 2020 4.22 [0.33; 53.77] MARIPOSA, 2021 1.43 [0.42; 4.87] 1.76[0.58; 5.29]Balcells, 2020, MARIPOSA, 202120%155moderatenot evaluable deathsdetailed resultsBalcells, 2020 3.26 [0.62; 17.12] Darazam, 2021 1.21 [0.65; 2.25] Li, 2021 1.04 [0.02; 53.73] Ranjbar, 2021 0.40 [0.15; 1.08] Wang, 2020 1.00 [0.02; 52.54] 0.99[0.48; 2.05]Balcells, 2020, Darazam, 2021, Li, 2021, Ranjbar, 2021, Wang, 2020528%454moderatenot evaluable deaths (time to event analysis only)detailed resultsBalcells, 2020 3.26 [0.62; 17.12] 3.26[0.62; 17.12]Balcells, 202010%58NAnot evaluable clinical deteriorationdetailed resultsBalcells, 2020 1.46 [0.44; 4.81] Li, 2021 0.52 [0.02; 15.78] Wang, 2020 1.00 [0.02; 52.54] 1.28[0.43; 3.77]Balcells, 2020, Li, 2021, Wang, 202030%200lownot evaluable clinical improvementdetailed resultsBalcells, 2020 0.91 [0.52; 1.60] Darazam, 2021 1.37 [0.88; 2.13] Li, 2021 1.76 [1.10; 2.81] 1.34[0.94; 1.90]Balcells, 2020, Darazam, 2021, Li, 2021336%322moderatenot evaluable clinical improvement (14-day)detailed resultsLi, 2021 2.86 [1.24; 6.62] 2.86[1.24; 6.62]Li, 202110%94NAnot evaluable clinical improvement (28-day)detailed resultsLi, 2021 4.26 [1.10; 16.44] 4.26[1.10; 16.44]Li, 202110%94NAnot evaluable clinical improvement (7-day)detailed resultsLi, 2021 1.83 [0.41; 8.14] 1.83[0.41; 8.14]Li, 202110%94NAnot evaluable clinical improvement (time to event analysis only)detailed resultsBalcells, 2020 0.91 [0.52; 1.60] Darazam, 2021 1.37 [0.88; 2.13] Li, 2021 1.76 [1.10; 2.81] 1.34[0.94; 1.90]Balcells, 2020, Darazam, 2021, Li, 2021336%322moderatenot evaluable death or ventilationdetailed resultsBalcells, 2020 0.67 [0.14; 3.26] 0.67[0.14; 3.26]Balcells, 202010%58NAnot evaluable hospital dischargedetailed resultsMARIPOSA, 2021 0.88 [0.55; 1.40] 0.88[0.55; 1.40]MARIPOSA, 202110%NAnot evaluable mechanical ventilationdetailed resultsBalcells, 2020 2.98 [0.41; 21.61] Li, 2021 0.52 [0.02; 15.78] MARIPOSA, 2021 0.88 [0.37; 2.10] Ranjbar, 2021 0.36 [0.13; 0.97] 0.72[0.33; 1.58]Balcells, 2020, Li, 2021, MARIPOSA, 2021, Ranjbar, 2021426%277moderatenot evaluable viral clearance detailed resultsBalcells, 2020 2.66 [0.69; 10.20] Li, 2021 7.68 [0.91; 65.15] 3.59[1.15; 11.21]Balcells, 2020, Li, 202120%141lownot evaluable viral clearance (time to event analysis only)detailed resultsLi, 2021 1.74 [1.10; 2.75] 1.74[1.10; 2.75]Li, 202110%96NAnot evaluable viral clearance by day 14detailed resultsLi, 2021 1.74 [0.71; 4.29] 1.74[0.71; 4.29]Li, 202110%94NAnot evaluable viral clearance by day 7detailed resultsBalcells, 2020 2.66 [0.69; 10.20] Li, 2021 2.20 [0.95; 5.10] 2.32[1.14; 4.73]Balcells, 2020, Li, 202120%141moderatenot evaluable related SAE (TRSAE)detailed resultsWang, 2020 2.04 [0.07; 63.93] 2.04[0.07; 63.93]Wang, 202010%48NAnot evaluable serious adverse eventsdetailed resultsBalcells, 2020 4.54 [0.20; 105.23] 4.54[0.20; 105.23]Balcells, 202010%58NAnot evaluable adverse eventsdetailed resultsWang, 2020 3.57 [0.93; 13.72] 3.57[0.93; 13.72]Wang, 202010%48NAnot evaluable0.510.01.0relative treatment effectwww.metaEvidence.org2024-05-03 21:43 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 95,94,90,91 - treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525 - roots T: 290