All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID-19 mild to moderate - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias deathsdetailed results Hung et al., 2020 0.47 [0.01; 24.30]
Solaymani-Dodaran, 2021 1.22 [0.66; 2.26]
1.20 [0.65 ; 2.19 ] Hung et al., 2020, Solaymani-Dodaran, 2021 2 0% 500 moderate not evaluable clinical deteriorationdetailed results ELACOI (lopinavir/ritonavir), 2020 3.69 [0.37; 36.57]
3.69 [0.37 ; 36.57 ] ELACOI (lopinavir/ritonavir), 2020 1 0% 28 NA not evaluable clinical improvementdetailed results Hung et al., 2020 3.92 [1.66; 9.24]
3.92 [1.66 ; 9.24 ] Hung et al., 2020 1 0% 127 NA not evaluable clinical improvement (time to event analysis only)detailed results Hung et al., 2020 3.92 [1.66; 9.24]
Solaymani-Dodaran, 2021 0.94 [0.75; 1.17]
1.80 [0.45 ; 7.27 ] Hung et al., 2020, Solaymani-Dodaran, 2021 2 90% 507 moderate not evaluable mechanical ventilationdetailed results Solaymani-Dodaran, 2021 1.62 [0.85; 3.08]
1.62 [0.85 ; 3.08 ] Solaymani-Dodaran, 2021 1 0% 373 NA not evaluable radiologic improvement (14-day)detailed results ELACOI (lopinavir/ritonavir), 2020 0.48 [0.02; 11.28]
0.48 [0.02 ; 11.28 ] ELACOI (lopinavir/ritonavir), 2020 1 0% 25 NA not evaluable radiologic improvement (7-day)detailed results ELACOI (lopinavir/ritonavir), 2020 0.10 [0.00; 2.09]
0.10 [0.00 ; 2.09 ] ELACOI (lopinavir/ritonavir), 2020 1 0% 25 NA not evaluable viral clearance detailed results ELACOI (lopinavir/ritonavir), 2020 1.28 [0.19; 8.76]
Hung et al., 2020 4.37 [1.86; 10.25]
3.24 [1.15 ; 9.10 ] ELACOI (lopinavir/ritonavir), 2020, Hung et al., 2020 2 24% 155 moderate not evaluable viral clearance (time to event analysis only)detailed results Hung et al., 2020 4.37 [1.86; 10.25]
4.37 [1.86 ; 10.25 ] Hung et al., 2020 1 0% 127 NA not evaluable viral clearance by day 14detailed results ELACOI (lopinavir/ritonavir), 2020 1.28 [0.19; 8.76]
ELACOI (Lopinavir/ritonavir), 2020 1.84 [0.40; 8.38]
1.60 [0.49 ; 5.27 ] ELACOI (lopinavir/ritonavir), 2020, ELACOI (Lopinavir/ritonavir), 2020 2 0% 97 moderate not evaluable viral clearance by day 7detailed results ELACOI (lopinavir/ritonavir), 2020 0.30 [0.05; 1.91]
ELACOI (Lopinavir/ritonavir), 2020 1.08 [0.41; 2.89]
0.73 [0.23 ; 2.33 ] ELACOI (lopinavir/ritonavir), 2020, ELACOI (Lopinavir/ritonavir), 2020 2 31% 97 moderate not evaluable ICU admissiondetailed results Solaymani-Dodaran, 2021 1.23 [0.70; 2.18]
1.23 [0.70 ; 2.18 ] Solaymani-Dodaran, 2021 1 0% 373 NA not evaluable severe COVID-19 occurrencedetailed results ELACOI (Lopinavir/ritonavir), 2020 0.30 [0.07; 1.27]
0.30 [0.07 ; 1.27 ] ELACOI (Lopinavir/ritonavir), 2020 1 0% 69 NA not evaluable serious adverse eventsdetailed results Hung et al., 2020 0.23 [0.01; 7.12]
0.23 [0.01 ; 7.12 ] Hung et al., 2020 1 0% 127 NA not evaluable 0.0 10.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-06 08:33 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 90
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290
