All patients
age >= 55 yr age >= 60 yr age >= 65 yr autoimmune disease corticosteroids: no corticosteroids: yes critical disease invasive ventilation no oxygen needed non invasive oxygen omicron variant BA.1 (B.1.1.529) severe disease solid organ transplant recipients subjects at risk
anti-inflammatoty and immuno-therapy in COVID-19 mild to moderate - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results CAN-COVID, 2020 0.67 [0.30; 1.50]
COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
CORIMUNO-ANA-1, 2021 0.91 [0.38; 2.19]
Pandit, 2021 0.95 [0.02; 50.33]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92]
0.67 [0.48 ; 0.93 ] CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Pandit, 2021, Shashi Bhushan, 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 6 0% 2,148 moderate not evaluable deathsdetailed results CAN-COVID, 2020 0.67 [0.30; 1.50]
COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
CORIMUNO-ANA-1, 2021 0.97 [0.46; 2.04]
Fu, 2020 1.00 [0.02; 51.66]
Libster, 2020 0.50 [0.09; 2.71]
LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21]
Pandit, 2021 0.95 [0.02; 50.33]
SAVE-MORE, 2021 0.45 [0.20; 0.99]
Shashi Bhushan, 2021 4.39 [0.20; 98.33]
Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92]
0.65 [0.50 ; 0.85 ] CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Fu, 2020, Libster, 2020, LIVE-AIR (Temesgen), 2021, Pandit, 2021, SAVE-MORE, 2021, Shashi Bhushan, 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 10 0% 3,461 moderate low deaths (time to event analysis only)detailed results LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21]
0.70 [0.40 ; 1.21 ] LIVE-AIR (Temesgen), 2021 1 0% 479 NA not evaluable clinical deteriorationdetailed results COL-COVID (Pascual-Figal), 2021 0.38 [0.09; 1.58]
CORIMUNO-ANA-1, 2021 0.89 [0.42; 1.92]
Libster, 2020 0.52 [0.29; 0.94]
SAVE-MORE, 2021 0.36 [0.26; 0.50]
0.48 [0.32 ; 0.73 ] COL-COVID (Pascual-Figal), 2021, CORIMUNO-ANA-1, 2021, Libster, 2020, SAVE-MORE, 2021 4 41% 377 low not evaluable clinical improvementdetailed results CAN-COVID, 2020 1.39 [0.76; 2.54]
Shashi Bhushan, 2021 0.68 [0.21; 2.20]
1.17 [0.64 ; 2.13 ] CAN-COVID, 2020, Shashi Bhushan, 2021 2 12% 688 moderate not evaluable clinical improvement (14-day)detailed results Pandit, 2021 8.77 [0.94; 81.67]
Shashi Bhushan, 2021 0.68 [0.21; 2.20]
2.03 [0.17 ; 24.32 ] Pandit, 2021, Shashi Bhushan, 2021 2 75% 281 moderate not evaluable clinical improvement (7-day)detailed results Shashi Bhushan, 2021 1.91 [1.03; 3.53]
1.91 [1.03 ; 3.53 ] Shashi Bhushan, 2021 1 0% 222 NA not evaluable death or ventilationdetailed results CORIMUNO-ANA-1, 2021 0.97 [0.62; 1.52]
LIVE-AIR (Temesgen), 2021 0.65 [0.43; 0.98]
Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.66 [0.46; 0.94]
0.73 [0.57 ; 0.93 ] CORIMUNO-ANA-1, 2021, LIVE-AIR (Temesgen), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 3 9% 1,313 moderate not evaluable hospital dischargedetailed results Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 1.48 [1.05; 2.09]
1.48 [1.05 ; 2.09 ] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 1 0% 1,197 NA not evaluable hospitalizationdetailed results Jagannathan, 2020 1.00 [0.14; 7.34]
1.00 [0.14 ; 7.34 ] Jagannathan, 2020 1 0% 120 NA not evaluable mechanical ventilationdetailed results COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
SAVE-MORE, 2021 0.47 [0.03; 7.48]
0.35 [0.04 ; 2.76 ] COL-COVID (Pascual-Figal), 2021, SAVE-MORE, 2021 2 0% 697 low not evaluable radiologic improvement (14-day)detailed results Rashad (CLARI vs SoC), 2021 2.87 [1.56; 5.28]
2.87 [1.56 ; 5.28 ] Rashad (CLARI vs SoC), 2021 1 0% 198 NA not evaluable viral clearance detailed results Jagannathan, 2020 0.81 [0.56; 1.18]
Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
1.61 [0.61 ; 4.25 ] Jagannathan, 2020, Pandit, 2021, Shashi Bhushan, 2021 3 82% 401 moderate not evaluable viral clearance (time to event analysis only)detailed results Jagannathan, 2020 0.81 [0.56; 1.18]
0.81 [0.56 ; 1.18 ] Jagannathan, 2020 1 0% 120 NA not evaluable viral clearance by day 14detailed results Pandit, 2021 10.23 [1.12; 93.35]
Shashi Bhushan, 2021 0.00 [0.00; 0.01]
0.18 [0.00 ; 435.69 ] Pandit, 2021, Shashi Bhushan, 2021 2 98% 1,359 moderate not evaluable viral clearance by day 7detailed results Pandit, 2021 2.33 [0.55; 9.83]
Shashi Bhushan, 2021 2.77 [1.44; 5.32]
2.69 [1.48 ; 4.87 ] Pandit, 2021, Shashi Bhushan, 2021 2 0% 281 moderate not evaluable ICU admissiondetailed results COL-COVID (Pascual-Figal), 2021 0.47 [0.08; 2.69]
Libster, 2020 0.33 [0.07; 1.58]
0.39 [0.12 ; 1.24 ] COL-COVID (Pascual-Figal), 2021, Libster, 2020 2 0% 263 low not evaluable serious adverse eventsdetailed results CAN-COVID, 2020 0.73 [0.45; 1.19]
COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41]
Jagannathan, 2020 1.00 [0.14; 7.34]
Pandit, 2021 0.95 [0.02; 50.33]
0.73 [0.46 ; 1.16 ] CAN-COVID, 2020, COL-COVID (Pascual-Figal), 2021, Jagannathan, 2020, Pandit, 2021 4 0% 710 moderate not evaluable adverse eventsdetailed results COL-COVID (Pascual-Figal), 2021 1.72 [0.73; 4.08]
Jagannathan, 2020 1.33 [0.63; 2.78]
Pandit, 2021 1.68 [0.47; 5.97]
1.51 [0.91 ; 2.52 ] COL-COVID (Pascual-Figal), 2021, Jagannathan, 2020, Pandit, 2021 3 0% 262 moderate not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2025-03-09 02:48 +01:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 90
- treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525
- roots T: 290