hydroxychloroquine - for COVID-19 method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

clinical improvement 1.51 [1.02, 2.22]> 113%3 studies (3 / -)98.1 %highnot evaluable lowcrucial-
clinical improvement (14-day) 1.29 [0.91, 1.84]> 10%3 studies (3 / -)92.5 %some concernnot evaluable moderatecrucial-
clinical improvement (time to event analysis only)no RCT reported results for this endpoint, but 4 observational studies are available. Clear RCT filter to include observational studies
clinical worsening 0.58 [0.07, 5.05]< 158%2 studies (2 / -)68.6 %highnot evaluable lowcrucial-
deaths 1.10 [0.98, 1.24]< 10%14 studies (14 / -)6.0 %some concernlow moderatecrucial-
deaths (time to event analysis only) 1.11 [0.98, 1.26]< 10%1 study (1 / -)5.2 %some concernnot evaluable moderatecrucial-
death or ventilationno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
hospitalization 0.83 [0.46, 1.50]< 10%3 studies (3 / -)73.4 %highnot evaluable lowimportant-
PCR-negative conversion 0.46 [0.04, 5.75]> 10%1 study (1 / -)27.7 %some concernnot evaluable moderateimportant-
PCR-negative conversion (14-day) 0.88 [0.28, 2.73]> 124%2 studies (2 / -)41.3 %some concernnot evaluable moderateimportant-
PCR-negative conversion (7-day) 1.12 [0.58, 2.19]> 10%2 studies (2 / -)63.2 %some concernnot evaluable moderateimportant-
PCR-negative conversion (time to event analysis only)no RCT reported results for this endpoint, but 4 observational studies are available. Clear RCT filter to include observational studies
radiologic improvement (14-day) 1.33 [0.94, 1.88]> 10%1 study (1 / -)94.7 %some concernnot evaluable moderateimportant-
radiologic improvement (7-day) 3.43 [1.10, 10.70]> 10%1 study (1 / -)98.3 %highnot evaluable lowimportant-
radiologic progression 0.57 [0.13, 2.50]< 10%1 study (1 / -)77.1 %some concernnot evaluable moderateimportant-
ventilationno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ventilation (time to event analysis only)no RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ICU admission 0.83 [0.35, 1.95]< 10%1 study (1 / -)66.8 %some concernnot evaluable moderatenon important-

-- safety endpoints 00

cardiac arrestno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
abnormal ECG findingsno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
arrhythmiano RCT reported results for this endpoint, but 4 observational studies are available. Clear RCT filter to include observational studies
diarrhea and abnormal liver function 1.45 [0.26, 8.01]< 10%1 study (1 / -)33.4 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 5 pathologies: 87,95,94,90,91,97 95, 97, 90, 94, 91