Immunosuppressants drugs - for COVID-19 method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

clinical improvement 1.23 [1.02, 1.49]> 10%4 studies (4 / -)98.3 %highnot evaluable lowcrucial-
clinical improvement (28-day) 1.19 [0.81, 1.75]> 10%1 study (1 / -)81.0 %some concernnot evaluable moderatecrucial-
clinical improvement (time to event analysis only) 1.15 [0.90, 1.47]> 10%1 study (1 / -)86.8 %lownot evaluable highcrucial-
clinical worsening 0.55 [0.33, 0.92]< 10%1 study (1 / -)98.9 %lownot evaluable highcrucial-
death or transfer to ICUno RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies
deaths 1.06 [0.72, 1.54]< 10%3 studies (3 / -)38.7 %highnot evaluable lowcrucial-
deaths (time to event analysis only)no RCT reported results for this endpoint, but 5 observational studies are available. Clear RCT filter to include observational studies
death or ventilation 0.54 [0.37, 0.79]< 10%3 studies (3 / -)99.9 %highnot evaluable lowimportant-
hospital discharge 0.25 [0.22, 0.28]> 10%1 study (1 / -)0.0 %lownot evaluable highimportant-
ventilation 0.27 [0.14, 0.55]< 10%2 studies (2 / -)100.0 %highnot evaluable lowimportant-
ICU admissionno RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies
off oxygenation 1.46 [0.79, 2.68]> 128%2 studies (2 / -)88.7 %highnot evaluable lownon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 2 pathologies: 87,95,94,90,91,97 91, 90