camostat mesilate - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.99 [0.29, 3.42]< 10%1 study (1/-)50.5 %some concernnot evaluable moderatecrucial-
death or transfer to ICU 0.55 [0.26, 1.17]< 10%1 study (1/-)93.9 %some concernnot evaluable moderatecrucial-
deaths 0.70 [0.20, 2.49]< 10%1 study (1/-)70.9 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.70 [0.20, 2.49]< 10%1 study (1/-)70.9 %some concernnot evaluable moderatecrucial-
clinical improvement 1.14 [0.83, 1.57]> 10%1 study (1/-)79.0 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.14 [0.83, 1.57]> 10%1 study (1/-)79.0 %some concernnot evaluable moderateimportant-
mechanical ventilation 2.27 [0.62, 8.26]< 10%1 study (1/-)10.7 %some concernnot evaluable moderateimportant-
mechanical ventilation (time to event analysis only) 0.69 [0.14, 3.42]< 10%1 study (1/-)67.5 %some concernnot evaluable moderateimportant-
ICU admission 0.80 [0.34, 1.90]< 10%1 study (1/-)69.4 %some concernnot evaluable moderatenon important-
recovery 1.18 [0.87, 1.61]> 10%1 study (1/-)85.4 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 1.84 [0.79, 4.30]< 10%1 study (1/-)8.0 %some concernnot evaluable moderateimportant-
adverse events 0.80 [0.43, 1.51]< 10%1 study (1/-)75.3 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.