Vitamins - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.50 [0.17, 1.50]< 10%1 study (1/-)89.2 %NAnot evaluable crucial-
deaths 0.94 [0.57, 1.56]< 119%6 studies (6/-)59.7 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.50 [0.17, 1.50]< 10%1 study (1/-)89.2 %NAnot evaluable crucial-
clinical deterioration 0.87 [0.23, 3.27]< 10%1 study (1/-)58.1 %NAnot evaluable important-
hospital discharge 0.99 [0.71, 1.38]> 10%1 study (1/-)47.6 %NAnot evaluable important-
mechanical ventilation 0.68 [0.39, 1.19]< 10%3 studies (3/-)91.2 %lownot evaluable highimportant-
viral clearance 6.33 [1.54, 26.00]> 10%1 study (1/-)99.5 %NAnot evaluable important-
ICU admission 0.17 [0.01, 3.79]< 186%2 studies (2/-)86.4 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 0.99 [0.02, 50.39]< 10%1 study (1/-)50.2 %NAnot evaluable important-
adverse events 1.99 [0.07, 59.94]< 10%1 study (1/-)34.8 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.