Table Graph
   

anti-inflammatory therapies - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.24 [0.07, 0.80]< 10%3 studies (2/1)99.0 %NAnot evaluable crucial-
deaths 0.40 [0.17, 0.95]< 10%4 studies (3/1)98.1 %NAnot evaluable crucial-
clinical deterioration 0.27 [0.01, 5.58]< 10%1 study (1/-)79.8 %NAnot evaluable important-
clinical improvement 10.27 [1.17, 90.18]> 10%1 study (1/-)98.2 %NAnot evaluable important-
clinical improvement (14-day) 10.27 [1.17, 90.18]> 10%1 study (1/-)98.2 %NAnot evaluable important-
clinical improvement (28-day) 3.52 [1.28, 9.72]> 10%2 studies (1/1)99.2 %NAnot evaluable important-
clinical improvement (7-day) 6.72 [1.50, 30.07]> 10%1 study (1/-)99.4 %NAnot evaluable important-
hospital discharge 2.04 [0.49, 8.46]> 176%2 studies (1/1)83.5 %NAnot evaluable important-
mechanical ventilation 0.59 [0.02, 14.04]< 10%1 study (1/-)62.7 %NAnot evaluable important-

safety endpoints 00

serious adverse events 1.08 [0.04, 32.96]< 10%1 study (1/-)48.3 %NAnot evaluable important-
adverse events 0.92 [0.41, 2.09]< 10%2 studies (2/-)57.9 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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