hydroxychloroquine plus macrolides - for COVID-19 method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

clinical worsening 0.99 [0.57, 1.72]< 10%1 study (1 / -)51.4 %some concernnot evaluable moderatecrucial-
death or transfer to ICUno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
deaths 0.60 [0.14, 2.54]< 10%1 study (1 / -)75.7 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only)no RCT reported results for this endpoint, but 5 observational studies are available. Clear RCT filter to include observational studies
hospitalizationno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ventilationno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
ventilation (time to event analysis only)no RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies

-- safety endpoints 00

cardiac arrestno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
abnormal ECG findingsno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
arrhythmiano RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 1 pathologies: 87,95,94,90,91,97 90