Outcome | Relative effect 95%CI | LoD | Trt. better when | I2 | k (RCT/OBS) | Bayesian probability | Overall ROB | Publication bias | Degree of certainty | Endpoint importance | Published MA | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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efficacy endpoints 00 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
deaths | 0.84 [0.45, 1.58] | < 1 | 49% | 3 studies (3/-) | 70.8 % | high | not evaluable | low | crucial | - | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
clinical improvement | 1.76 [1.25, 2.48] | > 1 | 0% | 3 studies (3/-) | 99.9 % | high | not evaluable | low | important | - | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
death or ventilation | 0.53 [0.30, 0.94] | < 1 | 20% | 2 studies (2/-) | 98.5 % | high | not evaluable | low | important | - | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ventilation | 0.27 [0.14, 0.55] | < 1 | 0% | 2 studies (2/-) | 100.0 % | high | not evaluable | low | important | - | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
off oxygenation | 1.46 [0.79, 2.68] | > 1 | 28% | 2 studies (2/-) | 88.7 % | high | not evaluable | low | non important | - |
LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies;
published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE.
Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.