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antiviral and associated therapy - versus control - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.97 [0.53, 1.77]< 10%6 studies (5/1)53.9 %seriousnot evaluable lowcrucial-
confirmed COVID (any severity) 0.91 [0.28, 2.98]< 10%1 study (-/1)56.1 %NAnot evaluable important-
conversion to SARS-CoV- 2–positive status via NP swab 0.78 [0.10, 6.26]< 195%2 studies (1/1)59.4 %NAnot evaluable important-
death or ventilation 0.85 [0.34, 2.13]< 10%1 study (-/1)63.6 %NAnot evaluable important-
hospitalization 1.15 [0.84, 1.57]< 10%4 studies (3/1)19.5 %seriousnot evaluable lowimportant-
new illness compatible with Covid-19 0.14 [0.05, 0.35]< 175%4 studies (3/1)100.0 %moderatenot evaluable moderateimportant-
symptomatic Covid-19 0.95 [0.71, 1.26]< 125%6 studies (6/-)64.2 %some concernnot evaluable moderateimportant-
asymptomatic COVID case 0.96 [0.49, 1.90]< 10%1 study (1/-)54.4 %NAnot evaluable non important-
ICU admission 1.00 [0.02, 52.45]< 10%1 study (1/-)50.0 %NAnot evaluable non important-
infection (PCR positive symptomatic or not) 0.91 [0.71, 1.17]< 118%10 studies (10/-)76.1 %some concernlow moderatenon important-

safety endpoints 00

serious adverse events 0.90 [0.47, 1.72]< 10%4 studies (4/-)62.9 %some concernnot evaluable moderateimportant-
adverse events 3.62 [1.25, 10.48]< 197%6 studies (6/-)0.9 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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