convalescent plasma treatment - versus control - for COVID 19 outpatients pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 5.02 [0.58, 43.27]< 10%1 study (1/-)7.2 %some concernnot evaluable moderatecrucial-
deaths 1.98 [0.07, 59.30]< 10%1 study (1/-)34.9 %some concernnot evaluable moderatecrucial-
hospitalization or death 0.91 [0.63, 1.33]< 10%1 study (1/-)68.1 %some concernnot evaluable moderatecrucial-
hospitalization 0.88 [0.57, 1.34]< 10%1 study (1/-)73.0 %some concernnot evaluable moderateimportant-
mechanical ventilation 1.49 [0.25, 9.02]< 10%1 study (1/-)33.2 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.