lopinavir/ritonavir - versus control - for COVID 19 outpatients pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.26 [0.01, 5.88]< 10%1 study (1/-)79.7 %some concernnot evaluable moderatecrucial-
hospitalization 0.76 [0.30, 1.90]< 10%1 study (1/-)72.1 %some concernnot evaluable moderateimportant-
viral clearance 0.92 [0.82, 1.03]> 10%1 study (1/-)6.7 %some concernnot evaluable moderateimportant-
viral clearance by day 14 0.92 [0.82, 1.03]> 10%1 study (1/-)6.7 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.