convalescent plasma treatment - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.47 [0.04, 5.69]< 10%1 study (1/-)72.1 %some concernnot evaluable moderatecrucial-
deaths 0.67 [0.42, 1.05]< 10%4 studies (4/-)96.0 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.93 [0.47, 1.85]< 10%1 study (1/-)58.2 %lownot evaluable highcrucial-
clinical improvement 1.11 [0.84, 1.47]> 120%3 studies (3/-)77.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 2.27 [0.90, 5.72]> 10%1 study (1/-)95.9 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.40 [0.85, 2.29]> 10%2 studies (2/-)90.7 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 0.98 [0.27, 3.58]> 10%1 study (1/-)48.8 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.12 [0.92, 1.36]> 10%3 studies (3/-)86.3 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.92 [0.52, 1.62]< 10%3 studies (3/-)61.3 %some concernnot evaluable moderateimportant-

safety endpoints 00

serious adverse events 0.95 [0.44, 2.05]< 170%2 studies (2/-)55.3 %lownot evaluable highimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.