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convalescent plasma treatment - versus standard of care - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.02 [0.64, 1.63]< 10%5 studies (5/-)46.2 %some concernnot evaluable moderatecrucial-
deaths 0.96 [0.76, 1.22]< 16%9 studies (9/-)62.4 %lownot evaluable highcrucial-
deaths (time to event analysis only) 3.20 [0.62, 16.39]< 10%1 study (1/-)8.2 %NAnot evaluable crucial-
clinical deterioration 0.63 [0.29, 1.40]< 10%1 study (1/-)87.0 %NAnot evaluable important-
clinical improvement 1.46 [0.84, 2.53]> 167%4 studies (4/-)91.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 2.27 [0.90, 5.72]> 10%1 study (1/-)95.9 %NAnot evaluable important-
clinical improvement (28-day) 1.61 [0.69, 3.76]> 174%3 studies (3/-)86.2 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 0.98 [0.27, 3.58]> 10%1 study (1/-)48.8 %NAnot evaluable important-
clinical improvement (time to event analysis only) 1.40 [0.79, 2.49]> 10%1 study (1/-)87.5 %NAnot evaluable important-
mechanical ventilation 0.67 [0.22, 2.02]< 10%1 study (1/-)76.1 %NAnot evaluable important-
mechanical ventilation (time to event analysis only) 0.66 [0.25, 1.72]< 10%1 study (1/-)80.2 %NAnot evaluable important-
viral clearance 1.12 [0.16, 7.84]> 10%1 study (1/-)54.5 %NAnot evaluable important-
viral clearance by day 14 1.51 [0.33, 6.94]> 10%1 study (1/-)70.1 %NAnot evaluable important-
ICU admission 0.82 [0.35, 1.91]< 10%1 study (1/-)67.7 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 1.50 [0.77, 2.92]< 172%2 studies (2/-)11.6 %some concernnot evaluable moderateimportant-
adverse events 1.08 [0.85, 1.38]< 10%1 study (1/-)26.7 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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