umifenovir (arbidol) - for COVID-19 method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

clinical improvementno RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
clinical improvement 0.68 [0.40, 1.14]> 10%1 study (1 / -)7.0 %some concernnot evaluable moderatecrucial-
clinical improvement (time to event analysis only)no RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
clinical worsening 0.86 [0.06, 11.36]< 10%1 study (1 / -)54.6 %some concernnot evaluable moderatecrucial-
PCR-negative conversion 2.80 [0.31, 25.53]> 10%1 study (1 / -)81.8 %some concernnot evaluable moderateimportant-
PCR-negative conversion (14-day) 2.80 [0.31, 25.53]> 10%1 study (1 / -)81.8 %some concernnot evaluable moderateimportant-
PCR-negative conversion (7-day) 0.67 [0.10, 4.58]> 10%1 study (1 / -)34.1 %some concernnot evaluable moderateimportant-
PCR-negative conversion (time to event analysis only)no RCT reported results for this endpoint, but 1 observational studies are available. Clear RCT filter to include observational studies
radiologic improvement (14-day) 0.18 [0.01, 3.99]> 10%1 study (1 / -)14.3 %some concernnot evaluable moderateimportant-
radiologic improvement (7-day) 0.08 [0.00, 1.71]> 10%1 study (1 / -)5.5 %some concernnot evaluable moderateimportant-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



This meta-analysis covered 1 pathologies: 87,95,94,90,91,97 87