favipiravir - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.78 [0.28, 2.22]< 10%5 studies (5/-)67.7 %some concernnot evaluable moderatecrucial-
clinical improvement 1.59 [1.21, 2.10]> 10%4 studies (4/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.26 [1.04, 1.53]> 10%3 studies (3/-)99.0 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.32 [0.86, 2.03]> 170%2 studies (2/-)89.4 %some concernnot evaluable moderateimportant-
clinical improvement (7-day) 1.50 [1.02, 2.21]> 10%1 study (1/-)97.9 %some concernnot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.67 [1.26, 2.23]> 10%2 studies (2/-)100.0 %some concernnot evaluable moderateimportant-
hospital discharge 1.41 [0.97, 2.03]> 10%1 study (1/-)96.6 %some concernnot evaluable moderateimportant-
PCR-negative conversion 1.75 [1.07, 2.87]> 163%6 studies (6/-)98.7 %some concernnot evaluable moderateimportant-
PCR-negative conversion (14-day) 1.12 [0.48, 2.63]> 132%3 studies (3/-)60.4 %some concernnot evaluable moderateimportant-
PCR-negative conversion (7-day) 1.44 [0.78, 2.65]> 161%3 studies (3/-)87.5 %some concernnot evaluable moderateimportant-
PCR-negative conversion (time to event analysis only) 1.32 [1.03, 1.69]> 10%2 studies (2/-)98.6 %some concernnot evaluable moderateimportant-
ventilation 0.06 [0.01, 0.83]< 10%1 study (1/-)98.2 %some concernnot evaluable moderateimportant-
ventilation (time to event analysis only) 0.06 [0.01, 0.83]< 10%1 study (1/-)98.2 %some concernnot evaluable moderateimportant-
ICU admission 1.21 [0.43, 3.39]< 10%2 studies (2/-)35.6 %some concernnot evaluable moderatenon important-

safety endpoints 00

serious adverse events 2.71 [0.41, 18.02]< 10%3 studies (3/-)15.3 %some concernnot evaluable moderateimportant-
adverse events 2.16 [0.82, 5.68]< 180%3 studies (3/-)5.9 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.