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lopinavir/ritonavir - versus hydroxychloroquine - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.49 [0.02, 14.80]< 10%1 study (1/-)65.8 %some concernnot evaluable moderatecrucial-
ICU admission 0.25 [0.05, 1.28]< 10%1 study (1/-)95.1 %some concernnot evaluable moderatenon important-

safety endpoints 00

arrhythmia 0.98 [0.02, 50.38]< 10%1 study (1/-)50.4 %some concernnot evaluable moderatenon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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