anticoagulant - versus control - for COVID-19 pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.22 [0.07, 0.67]< 10%1 study (1/-)99.6 %some concernnot evaluable moderatecrucial-
death or transfer to ICU 0.70 [0.44, 1.12]< 10%1 study (1/-)93.1 %some concernnot evaluable moderatecrucial-
deaths 0.99 [0.74, 1.33]< 163%5 studies (5/-)52.3 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.97 [0.50, 1.86]< 175%2 studies (2/-)54.1 %some concernnot evaluable moderateimportant-
clinical improvement 0.83 [0.67, 1.03]> 10%1 study (1/-)4.5 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.27 [1.03, 1.57]> 10%1 study (1/-)98.6 %some concernnot evaluable moderateimportant-
death or ventilation 0.76 [0.58, 1.00]< 111%2 studies (2/-)97.6 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.70 [0.32, 1.54]< 10%1 study (1/-)81.1 %some concernnot evaluable moderateimportant-
ICU admission 0.79 [0.48, 1.30]< 10%1 study (1/-)82.5 %some concernnot evaluable moderatenon important-
Major thrombotic events or death 1.04 [0.80, 1.36]< 10%1 study (1/-)38.7 %some concernnot evaluable moderatenon important-

safety endpoints 00

Major bleeding 1.75 [1.14, 2.69]< 10%4 studies (4/-)0.5 %some concernnot evaluable moderatenon important-

AE of interest endpoints 00

Thromboembolic events 0.95 [0.68, 1.34]< 121%2 studies (2/-)61.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.