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lopinavir/ritonavir - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.81 [0.65, 1.03]< 10%2 studies (2/-)95.7 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.83 [0.65, 1.06]< 10%1 study (1/-)92.9 %NAnot evaluable crucial-
clinical improvement 1.31 [0.94, 1.83]> 10%1 study (1/-)94.4 %NAnot evaluable important-
clinical improvement (14-day) 1.23 [0.55, 2.76]> 184%2 studies (2/-)69.5 %some concernnot evaluable moderateimportant-
clinical improvement (28-day) 1.59 [0.84, 3.03]> 10%1 study (1/-)92.1 %NAnot evaluable important-
clinical improvement (7-day) 3.16 [0.62, 16.06]> 10%1 study (1/-)91.7 %NAnot evaluable important-
clinical improvement (time to event analysis only) 1.31 [0.94, 1.83]> 10%1 study (1/-)94.4 %NAnot evaluable important-
hospital discharge 0.83 [0.69, 1.00]> 10%1 study (1/-)2.6 %NAnot evaluable important-

safety endpoints 00

serious adverse events 0.88 [0.30, 2.58]< 177%2 studies (2/-)59.0 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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