Study		Exclusion reasons	Remarks	Reference(s)
HYDRA, 2020	randomized controlled trial		Initially found in Axfors et al. meta-analysis results published by Hernadez et al
Duke university (Hydroxychloroquine), 2020	randomized controlled trial	cancelled by investigator
Duke University azithromycin, 2020	randomized controlled trial	cancelled by investigator	Discontinuated : Poor recruitment, strong evidence from larger trials of no therapeutic benefit
Erdem, 2020	retrospective cohort (registry)	no control group		Erdem HA Turk J Med Sci 2020 Nov 25. 10.3906/sag-2008-33
Yamamura, 2020	single-arm	no control group		Yamamura H Crit Care 2020 Jul 9;24(1):413. 10.1186/s13054-020-03137-5
Murohashi, 2020	prospective cohort	no control group		Murohashi K Respir Investig 2020 Aug 28;58(6):430-434. 10.1016/j.resinv.2020.08.001
SIMPLE (Grein), 0	single-arm	no control group	single-arm with external control group	Grein N. Engl. J. Med. 2020; 382:2327-2336 10.1056/NEJMoa2007016
Niaee (vs placebo), 2020	randomized controlled trial	other	On 8 October 2021 and 9 October 2021, two articles were published by subject-matter experts outlining concerns about various aspects of the study and, in particular, calling into question the randomization of participants. The authors and publishing journal have been alerted to these issues, and this note will be updated with any new information related to the publication.	Niaee MS et al. researchsquare 10.21203/rs.3.rs-109670/v1 Niaee MS et al. Asian Pacific Journal of Tropical Medicine 10.4103/1995-7645.318304

Study

Exclusion reasons

Remarks

Reference(s)

randomized controlled trial

Initially found in Axfors et al. meta-analysis results published by Hernadez et al

randomized controlled trial

cancelled by investigator

randomized controlled trial

cancelled by investigator

Discontinuated : Poor recruitment, strong evidence from larger trials of no therapeutic benefit

retrospective cohort (registry)

no control group

Erdem HA Turk J Med Sci 2020 Nov 25. 10.3906/sag-2008-33

single-arm

no control group

Yamamura H Crit Care 2020 Jul 9;24(1):413. 10.1186/s13054-020-03137-5

prospective cohort

no control group

Murohashi K Respir Investig 2020 Aug 28;58(6):430-434. 10.1016/j.resinv.2020.08.001

single-arm

no control group

single-arm with external control group

Grein N. Engl. J. Med. 2020; 382:2327-2336 10.1056/NEJMoa2007016

randomized controlled trial

other

On 8 October 2021 and 9 October 2021, two articles were published by subject-matter experts outlining concerns about various aspects of the study and, in particular, calling into question the randomization of participants. The authors and publishing journal have been alerted to these issues, and this note will be updated with any new information related to the publication.

Niaee MS et al. researchsquare 10.21203/rs.3.rs-109670/v1

Niaee MS et al. Asian Pacific Journal of Tropical Medicine 10.4103/1995-7645.318304