Study Exclusion reasons Remarks Reference(s)
HYDRA, 2020 randomized controlled trial Initially found in Axfors et al. meta-analysis results published by Hernadez et al  
Duke university (Hydroxychloroquine), 2020 randomized controlled trial cancelled by investigator  
Duke University azithromycin, 2020 randomized controlled trial cancelled by investigator Discontinuated : Poor recruitment, strong evidence from larger trials of no therapeutic benefit  
Erdem, 2020 retrospective cohort (registry) no control group

Erdem HA Turk J Med Sci 2020 Nov 25. 10.3906/sag-2008-33

 
Yamamura, 2020 single-arm no control group

Yamamura H Crit Care 2020 Jul 9;24(1):413. 10.1186/s13054-020-03137-5

 
Murohashi, 2020 prospective cohort no control group

Murohashi K Respir Investig 2020 Aug 28;58(6):430-434. 10.1016/j.resinv.2020.08.001

 
SIMPLE (Grein), 0 single-arm no control group single-arm with external control group

Grein N. Engl. J. Med. 2020; 382:2327-2336 10.1056/NEJMoa2007016

 
Niaee (vs placebo), 2020 randomized controlled trial other On 8 October 2021 and 9 October 2021, two articles were published by subject-matter experts outlining concerns about various aspects of the study and, in particular, calling into question the randomization of participants. The authors and publishing journal have been alerted to these issues, and this note will be updated with any new information related to the publication.

Niaee MS et al. researchsquare 10.21203/rs.3.rs-109670/v1

Niaee MS et al. Asian Pacific Journal of Tropical Medicine 10.4103/1995-7645.318304