azithromycin plus hydroxychloroquine (n=152) vs. placebo (n=152)
randomized controlled trial
Hydroxychloroquine plus azithromycin
HCQ : 600 mg daily for one weekAZI : 500 mg day one,250 mg daily on days two through five
placebo
3 arms: Hydroxychloroquine plus azithromycin, hydroxychloroquine monotherapy, and placebo (1:1:1 ratio)
COVID 19 outpatients
Double-blind.
Multicenter: 2 centres in Doha, Qatar.
Rodrigues, 2021
azithromycin plus hydroxychloroquine (n=42) vs. placebo (n=42)
randomized controlled trial
Hydroxychloroquine plus azithromycin
200 mg HCQ capsules twice a day for a total course of seven days and one 500 mg AZT capsule taken on day 1, followed by one 250 mg AZT capsule daily for the next four days (i.e. 6 capsules in total).
Placebo
The placebo capsules were formulated to have similar size, shape, color and taste as hydroxychloroquine and azithromycin capsules, and with an identical dosing regimen.
COVID 19 outpatients
Age between 18 and 65 years, Flu-like symptoms beginning 2-5 days prior, Infection by SARS-CoV-2, Not requiring hospital admittance, Consenting to study participation.
Double-blind.
Single center: Hospital Santa Paula, Sao Paulo, Brazil.
