Sobi.IMMUNO-101 (anakinra), 0 NCT04324021
anakinra vs. standard of care
COVID 19 all comers
ChiCTR2000030028, 0 ChiCTR2000030028
anti-PD-1 antibody vs. standard of care
COVID 19 all comers
RECOVERY, 2022 NCT04381936
baricitinib vs. standard of care
COVID 19 all comers
INHASCO, 0 NCT04331054
budesonide vs. standard of care
COVID 19 all comers
KUMC-COVID-19 (ciclesonide), 0 NCT04330586
ciclesonide vs. standard of care
COVID 19 all comers
Chen, 2022
cilgavimab and tixagevimab (Evusheld) vs. control
COVID 19 all comers
ChiCTR2000030702, 0 ChiCTR2000030702
convalescent plasma treatment vs. control
COVID 19 all comers
ChiCTR2000030929, 0 ChiCTR2000030929
convalescent plasma treatment vs. placebo
COVID 19 all comers
NCT04323800, 0 NCT04323800
convalescent plasma treatment vs. standard of care
COVID 19 all comers
ChiCTR2000030039, 0 ChiCTR2000030039
convalescent plasma treatment vs. standard of care
COVID 19 all comers
LIFESAVER, 2021 NCT04374526
convalescent plasma treatment vs. standard of care
COVID 19 all comers
NCT04425837, 0 NCT04425837
convalescent plasma treatment vs. standard of care
COVID 19 all comers
TSUNAMI, 0 NCT04393727
convalescent plasma treatment vs. standard of care
COVID 19 all comers
MP-C19, 0 NCT04323592
corticosteroids vs. control
COVID 19 all comers
NCT04360876, 0 NCT04360876
corticosteroids vs. placebo
COVID 19 all comers
ChiCTR2000030481, 0 ChiCTR2000030481
corticosteroids vs. standard of care
COVID 19 all comers
Sobi.IMMUNO-101 (emapalumab), 0 NCT04324021
emapalumab vs. standard of care
COVID 19 all comers
ChiCTR2000030016, 0 ChiCTR2000030016
inactivated mycobacterium vaccine vs. standard of care
COVID 19 all comers
Cai -FAVIPIRAVIR, 2020 ChiCTR2000029600
interferon vs. interferon
COVID 19 all comers
Cai -FAVIPIRAVIR, 2020 ChiCTR2000029600
interferon vs. lopinavir/ritonavir
COVID 19 all comers
ChiCTR2000029989, 0 ChiCTR2000029989
interferon vs. placebo
COVID 19 all comers
Wang, 2020 ChiCTR2000030058
leflunomide vs. interferon
COVID 19 all comers
NCT04331470, 0 NCT04331470
levamisole vs. lopinavir/ritonavir plus chloroquine
COVID 19 all comers
Yin Wang et al., 2020
low-dose corticosteroids vs. control
COVID 19 all comers
NCT04282902, 0 NCT04282902
pirfenidone vs. standard of care
COVID 19 all comers
ChiCTR2000030333, 0 ChiCTR2000030333
pirfenidone vs. standard of care
COVID 19 all comers
The First Affiliated of Wenzhou Medical University, 0 ChiCTR2000029776
Polyinosinic-Polycytidylic Acid vs. standard of care
COVID 19 all comers
ruxolitinib NOVARTIS, 0
ruxolitinib vs. control
COVID 19 all comers
TOCIVID (sarilumab), 0 NCT04322773
sarilumab vs. standard of care
COVID 19 all comers
sarilumab phase 2 high dose, 0 NCT04315298
sarilumab high dose (400mg) vs. placebo
COVID 19 all comers
sarimulab phase 2 low dose, 0 NCT04315298
sarilumab low dose (200mg) vs. placebo
COVID 19 all comers
add-on-COV2, 0 NCT04322344
sodium aescinate vs. standard of care
COVID 19 all comers
NCT04293692, 0 NCT04293692
stem cells vs. placebo
COVID 19 all comers
NCT04288102, 0 NCT04288102
stem cells vs. placebo
COVID 19 all comers
ChiCTR2000030484, 0 ChiCTR2000030484
stem cells vs. standard of care
COVID 19 all comers
ChiCTR2000029580, 0 ChiCTR2000029580
stem cells vs. standard of care
COVID 19 all comers
First Affiliated Hospital of Wenzhou Medical University, 0 NCT04273581
thalidomide vs. placebo
COVID 19 all comers
ChiCTR2000030894 -TOCI, 0 ChiCTR2000030894
tocilizumab vs. favipiravir
COVID 19 all comers
NCT04356937, 0 NCT04356937
tocilizumab vs. placebo
COVID 19 all comers
BACC Bay Tocilizumab Trial, 2020 NCT04356937
tocilizumab vs. placebo
COVID 19 all comers
TOCIVID (tocilizumab), 0 NCT04322773
tocilizumab vs. standard of care
COVID 19 all comers
TOCOVID, 0 NCT04332094
tocilizumab vs. standard of care
COVID 19 all comers
NCT04330638, 0 NCT04330638
tocilizumab vs. standard of care
COVID 19 all comers
NCT04326426, 0 NCT04326426
tradipitant vs. placebo
COVID 19 all comers
CALAVI, 2020 NCT04346199
acalabrutinib vs. standard of care
COVID 19 hospitalized
CALAVI US, 2020 NCT04380688
acalabrutinib vs. standard of care
COVID 19 hospitalized
NCT04647669, 0 NCT04647669
acalabrutinib vs. standard of care
COVID 19 hospitalized
ACTIV-3 (BRII-196 and BRII-198), 2021 NCT04501978
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences) vs. placebo
COVID 19 hospitalized
SAVE-MORE, 2021 NCT04680949
anakinra vs. placebo
COVID 19 hospitalized
ANA-COVID-GEAS, 0 NCT04443881
anakinra vs. standard of care
COVID 19 hospitalized
Malgorzata, 2020
anti-inflammatory therapies vs. control
COVID 19 hospitalized
ACTIV-3/TICO LY-CoV555 , 2020 NCT04501978
bamlanivimab monotherapy vs. placebo
COVID 19 hospitalized
COV-BARRIER, 2021 NCT04421027
baricitinib vs. placebo
COVID 19 hospitalized
ACTT-2 (Kalil), 2020 NCT04401579
baricitinib vs. placebo
COVID 19 hospitalized
Sheng (Three C Study), 2020 NCT04365153
canakinumab vs. placebo
COVID 19 hospitalized
RECOVERY (REGN-COV2), 2021 NCT04381936
casirivimab/imdevimab (Ronapreve) vs. standard of care
COVID 19 hospitalized
Wenxin, 2020 ChiCTR2000031630.
Celecoxib vs. control
COVID 19 hospitalized
ACTIV-3/TICO (tixa), 2022 NCT04501978
cilgavimab and tixagevimab (Evusheld) vs. placebo
COVID 19 hospitalized
Tsiakos, 2020 NCT04398004
clarithromycine vs. azithromycin plus hydroxychloroquine
COVID 19 hospitalized
Lopes MIF, 2020 RBR-8jyhxh
colchicine vs. placebo
COVID 19 hospitalized
Salehzadeh, 2020 IRCT20200418047126N1
colchicine vs. placebo
COVID 19 hospitalized
COLCOVID, 2021 NCT04328480
colchicine vs. standard of care
COVID 19 hospitalized
Scarsi, 2020
colchicine vs. standard of care
COVID 19 hospitalized
GRECCO-19, 2020 NCT04326790
colchicine vs. standard of care
COVID 19 hospitalized
RECOVERY (colchicine), 2021 NCT04381936
colchicine vs. standard of care
COVID 19 hospitalized
Horby, 2021 NCT04381936
colchicine vs. standard of care
COVID 19 hospitalized
Sandhu, 2020
colchicine vs. standard of care
COVID 19 hospitalized
COLSTAT, 2021 NCT04472611
Colchicine plus rosuvastatin vs. standard of care
COVID 19 hospitalized
Gaitan-Duarte (Rosuvastatin plus colchicine), 2021 NCT04359095
Colchicine plus rosuvastatin vs. standard of care
COVID 19 hospitalized
Abolghasemi, 2020 IRCT20200325046860N1
convalescent plasma treatment vs. control
COVID 19 hospitalized
Salazar, 2020
convalescent plasma treatment vs. control
COVID 19 hospitalized
ESCAPE, 0 NCT04361253
convalescent plasma treatment vs. control
COVID 19 hospitalized
COVIPLASM (CORIMUNO-19 substudy), 0 NCT04345991
convalescent plasma treatment vs. control
COVID 19 hospitalized
C3PO, 0 NCT04355767
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
PassItOnII, 0 NCT04362176
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
CONTAIN COVID-19, 2021 NCT04364737
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
EPCOvid-1, 0 NCT04388410
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
CPC-SARS, 2021 NCT04405310
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
CAPRI, 0 NCT04421404
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
NCT04442191, 2021 NCT04442191
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
PROMETEO, 0 NCT04452812
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
Bennett-Guerrero, 2021 NCT04344535
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
LACCPT, 2021 PACTR202006760881890
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
CCAP-2, 2021 NCT04345289
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
Baldeon, 2022 SRCTN85216856
convalescent plasma treatment vs. placebo
COVID 19 hospitalized
ConCOVID (Gharbharan et al.), 2020 NCT04342182
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Dai W, 2020
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
ConPlas-19, 2020 NCT04345523
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
COP-COVID-19, 2021 NCT04358783
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
PC/COVID-19, 2021 NCT04366245
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04456413, 0 NCT04456413
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
CONCOR-KIDS, 0 NCT04377568
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04397757, 2021 NCT04397757
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
PLACO-COVID, 2021 NCT04428021
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
CONCOR-1, 2021 NCT04348656
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
SARS-CoV-2CP-HD-001, 0 2020-001632-10
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
DAWN-Plasma, 2021 NCT04429854
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
PLASCOSSA, 0 NCT04372979
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04385199, 2021 NCT04385199
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04391101, 0 NCT04391101
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04385186, 0 NCT04385186
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04395170, 0 NCT04395170
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
COPLA-II trial, 2020 NCT04425915
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04380935, 0 NCT04380935
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04403477 (two doses), 2021 NCT04403477
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
ASCOT, 2021 NCT04483960
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04374487 , 0 NCT04374487
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
RECOVERY (plasma), 2021 NCT04381936
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04649879, 0 NCT04649879
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
CONFIDENT, 2020 NCT04558476
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
PERUCONPLASMA, 2021 NCT04497324
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Salman, 2020 NCT04530370
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Kirenga, 2021 NCT04542941
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Co-CLARITY, 2021 NCT04567173
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
NCT04528368, 2021 NCT04528368
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Holm K, 2021 NCT04600440
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Bargay-Lleonart, 2022
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Menichetti, 2021 NCT04716556
convalescent plasma treatment vs. standard of care
COVID 19 hospitalized
Rahman, 2020 IRB 2005800938
corticosteroids vs. control
COVID 19 hospitalized
Albani, 2020
corticosteroids vs. control
COVID 19 hospitalized
SAM-COVID-19, 2020
corticosteroids vs. control
COVID 19 hospitalized
Rodriguez-Bano (intermediate-high dose CS), 2020
corticosteroids vs. control
COVID 19 hospitalized
Rodriguez-Bano (CS pulse dose), 2020
corticosteroids vs. control
COVID 19 hospitalized
Fernández Cruz, 2020
corticosteroids vs. standard of care
COVID 19 hospitalized
GLUCOCOVID, 2020 2020-001934- 37
corticosteroids vs. standard of care
COVID 19 hospitalized
Villar, 2020 NCT04325061
dexamethasone vs. control
COVID 19 hospitalized
RECOVERY dexamethasone, 2020 NCT04381936
dexamethasone vs. standard of care
COVID 19 hospitalized
Balcells, 2020 NCT04375098
Early convalescent plasma. vs. Deferred Convalescent plasma
COVID 19 hospitalized
Darazam, 2021 NCT04521400
high-dose IFN beta-1a vs. IFN beta-1a
COVID 19 hospitalized
SOLIDARITY (interferon), 2020 NCT04315948
IFN beta-1a vs. control
COVID 19 hospitalized
Esquivel-Moynelo, 2020 RPCEC00000307
IFN gamma vs. standard of care
COVID 19 hospitalized
Sakoulas, 2020 NCT04411667
immunoglobulin therapy vs. standard of care
COVID 19 hospitalized
Parikh, 2021 CTRI/2020/09/027903
immunoglobulin therapy vs. standard of care
COVID 19 hospitalized
Wang (early IFN), 2020
interferon vs. control
COVID 19 hospitalized
Wang, 2020
interferon vs. lopinavir/ritonavir
COVID 19 hospitalized
NCT04350671, 0
interferon vs. placebo
COVID 19 hospitalized
Wang et al., 2020
leflunomide vs. standard of care
COVID 19 hospitalized
NCT04351152, 0 NCT04351152
lenzilumab vs. standard of care
COVID 19 hospitalized
MASH-COVID (Cremer), 2021 NCT04399980
mavrilimumab vs. placebo
COVID 19 hospitalized
Huijie Bian, 2020 NCT 04275245
meplazumab vs. standard of care
COVID 19 hospitalized
Ranjbar, 2021 IRCT20200204046369N1
methylprednisolone vs. dexamethasone
COVID 19 hospitalized
Tang X, 2020 NCT04273321
methylprednisolone vs. placebo
COVID 19 hospitalized
Metcovid, 2020 NCT04343729
methylprednisolone vs. placebo
COVID 19 hospitalized
ITAC, 2022 NCT04546581
neutralizing antibody vs. placebo
COVID 19 hospitalized
Jeong, 2020
non-steroidal anti-inflammatory drugs vs. control
COVID 19 hospitalized
Bruce, 2020
non-steroidal anti-inflammatory drugs vs. control
COVID 19 hospitalized
Imam, 2020
non-steroidal anti-inflammatory drugs vs. control
COVID 19 hospitalized
Drake, 2021
non-steroidal anti-inflammatory drugs vs. control
COVID 19 hospitalized
NCT04432298, 2020 NCT04432298
pamrevlumab vs. standard of care
COVID 19 hospitalized
Li, 2021 ChiCTR2000029638
recombinant super-compound interferon rSIFN-co vs. IFN alpha
COVID 19 hospitalized
CORIMUNO-SARI-1 (non ICU), 2021 NCT04324073
sarilumab vs. standard of care
COVID 19 hospitalized
SARICOR, 0 NCT04357860
sarilumab vs. standard of care
COVID 19 hospitalized
SARCOVID, 0 NCT04357808
sarilumab vs. standard of care
COVID 19 hospitalized
NCT04349098, 0 NCT04349098
selinexor vs. placebo
COVID 19 hospitalized
Synairgen SG016, 2020 NCT04385095
SNG001 inhaled interferon beta vs. placebo
COVID 19 hospitalized
SPRINTER, 2022 NCT04732949
SNG001 inhaled interferon beta vs. placebo
COVID 19 hospitalized
ACTIV-3/ TICO (sotrovimab), 2021 NCT04501978
sotrovimab (Xevudy; VIR-7831) vs. placebo
COVID 19 hospitalized
Lanzoni, 2021 NCT04355728
stem cells vs. placebo
COVID 19 hospitalized
Carmenate (SENTAD-COVID), 2021 NCT04473170
stem cells vs. standard of care
COVID 19 hospitalized
Martinez-Sanz, 2020
tocilizumab vs. control
COVID 19 hospitalized
HNF Hospital Tocilizumab multidisciplinary team, 2020
tocilizumab vs. control
COVID 19 hospitalized
Colaneri, 2020
tocilizumab vs. control
COVID 19 hospitalized
Tsai, 2020
tocilizumab vs. control
COVID 19 hospitalized
SAM-COVID-19, 2020
tocilizumab vs. control
COVID 19 hospitalized
EMPACTA, 2020 NCT04372186
tocilizumab vs. placebo
COVID 19 hospitalized
NCT04412772 (ARCHITECTS), 0 NCT04412772
tocilizumab vs. placebo
COVID 19 hospitalized
Dongsheng Wang, 2020 ChiCTR2000029765
tocilizumab vs. standard of care
COVID 19 hospitalized
RCT-TCZ-COVID-19, 2021 NCT04346355
tocilizumab vs. standard of care
COVID 19 hospitalized
RECOVERY, 2021 NCT04381936
tocilizumab vs. standard of care
COVID 19 hospitalized
Soin AS (COVINTOC), 2021 CTRI/2020/05/025369
tocilizumab vs. standard of care
COVID 19 hospitalized
Rutgers, 2021
tocilizumab vs. standard of care
COVID 19 hospitalized
Declercq J (COV-AID), 2021 NCT04330638
tocilizumab vs. standard of care
COVID 19 hospitalized
NCT04577534 (COVIDSTORM), 0 NCT04577534
tocilizumab vs. standard of care
COVID 19 hospitalized
EU-CTR2020-001375-32 (PreToVid), 0 EU-CTR2020-001375-32
tocilizumab vs. standard of care
COVID 19 hospitalized
EU-CTR2020-001748-24 (ImmCoVA), 0 EU-CTR2020-001748-24
tocilizumab vs. standard of care
COVID 19 hospitalized
NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0 NCT04479358
tocilizumab vs. standard of care
COVID 19 hospitalized
NCT04434717 (COVITOZ-1 single dose plus two doses), 0 NCT04434717
tocilizumab vs. standard of care
COVID 19 hospitalized
STOP-COVID (Guimarães), 2021 NCT04469114
tofacitinib vs. placebo
COVID 19 hospitalized
phase 2, 0 NCT04787211
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences) vs. placebo
COVID-19 mild to moderate
CORIMUNO-ANA-1, 2021 NCT04341584
anakinra vs. control
COVID-19 mild to moderate
CORIMUNO-NIVO, 0 NCT04343144
anti-PD-1 antibody vs. standard of care
COVID-19 mild to moderate
NCT04446377, 0 NCT04446377
Apilimod vs. standard of care
COVID-19 mild to moderate
Rodriguez-Garcia, 2020 EUPAS34966
baricitinib vs. standard of care
COVID-19 mild to moderate
Cantini, 2020
baricitinib vs. standard of care
COVID-19 mild to moderate
Cantini, 2020
baricitinib vs. standard of care
COVID-19 mild to moderate
CORIMMUNO-BEVA, 0 NCT04344782
bevacizumab vs. standard of care
COVID-19 mild to moderate
Suzuki, 2021
casirivimab/imdevimab (Ronapreve) vs. control
COVID-19 mild to moderate
Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 NCT04426695
casirivimab/imdevimab (Ronapreve) vs. placebo
COVID-19 mild to moderate
Rashad (CLARI vs SoC), 2021
clarithromycine vs. standard of care
COVID-19 mild to moderate
Yamamoto (CAME COVID), 2021 jRCTs071210011
clarithromycine vs. standard of care
COVID-19 mild to moderate
COL-COVID (Pascual-Figal), 2021 NCT04350320
colchicine vs. standard of care
COVID-19 mild to moderate
Libster, 2020 NCT04479163
convalescent plasma treatment vs. placebo
COVID-19 mild to moderate
CORIPLASM, 0 NCT04345991
convalescent plasma treatment vs. standard of care
COVID-19 mild to moderate
PLACID, 2020 CTRI/2020/04/024775
convalescent plasma treatment vs. standard of care
COVID-19 mild to moderate
Li (Methylprednisolone, Shanghai cohort), 2020
corticosteroids vs. control
COVID-19 mild to moderate
Majmundar, 2020
corticosteroids vs. control
COVID-19 mild to moderate
Vergis, 2021 NCT04581954
fostamatinib vs. standard of care
COVID-19 mild to moderate
Covid-19 HUF, 2021 NCT04346147
imatinib vs. lopinavir/ritonavir plus chloroquine
COVID-19 mild to moderate
Ravichandran, 2020
Indomethacin vs. paracetamol
COVID-19 mild to moderate
Ravichandran, 2021 CTRI/2021/05/033544
Indomethacin vs. paracetamol
COVID-19 mild to moderate
NCT04343768, 0 NCT04343768
interferon vs. interferon
COVID-19 mild to moderate
Hassaniazad, 2020 IRCT20200506047323N3
interferon vs. lopinavir/ritonavir plus interferon ß-1a
COVID-19 mild to moderate
COVID-Lambda, 0 NCT04331899
interferon vs. standard of care
COVID-19 mild to moderate
Fu, 2020 ChiCTR2000030262
interferon / TFF2 vs. standard of care
COVID-19 mild to moderate
LIVE-AIR (Temesgen), 2021 NCT04351152
lenzilumab vs. placebo
COVID-19 mild to moderate
Pupim, 2021
mavrilimumab vs. placebo
COVID-19 mild to moderate
Guzman-Esquivel, 2022
non-steroidal anti-inflammatory drugs vs. placebo
COVID-19 mild to moderate
Jagannathan, 2020 NCT04331899
peginterferon vs. placebo
COVID-19 mild to moderate
Pandit, 2021 CTRI/2020/06/026087
pegylated interferon-α2b vs. standard of care
COVID-19 mild to moderate
Shashi Bhushan, 2021 CTRI/2020/12/029855
pegylated interferon-α2b vs. standard of care
COVID-19 mild to moderate
Lattmann, 2021 CTRI/2020/10/028423
PNB001 vs. standard of care
COVID-19 mild to moderate
Vergis, 2021 NCT04581954
ruxolitinib vs. standard of care
COVID-19 mild to moderate
Capra, 2020
tocilizumab vs. control
COVID-19 mild to moderate
NCT04345445, 0 NCT04345445
tocilizumab vs. corticosteroids
COVID-19 mild to moderate
Murugesan, 2022
tofacitinib vs. standard of care
COVID-19 mild to moderate
POLYCOR phase IIb (Gaborit), 2021 NCT04453384
XAV-19 vs. placebo
COVID-19 mild to moderate
ACTIV-1 abatacept, 2020 NCT04593940
abatacept vs. placebo
COVID-19 severe or critically
Fakharian, 2021 IRCT20151227025726N2
adalimumab vs. standard of care
COVID-19 severe or critically
Ana-COVID (Huet), 2020
anakinra vs. control
COVID-19 severe or critically
Kooistra, 2020
anakinra vs. standard of care
COVID-19 severe or critically
ChiCTR2000029806 (camrelizumab), 0 ChiCTR2000029806
anti-PD-1 antibody vs. standard of care
COVID-19 severe or critically
COPERNICO, 0 NCT04335305
anti-PD-1 antibody vs. tocilizumab
COVID-19 severe or critically
INSPIRATION-S, 2022 NCT04486508
Atorvastatin vs. placebo
COVID-19 severe or critically
COV-BARRIER (critically ill), 2022 NCT04421027
baricitinib vs. placebo
COVID-19 severe or critically
Tziolos, 2021
baricitinib vs. standard of care
COVID-19 severe or critically
CAN-COVID, 2020 NCT04362813
canakinumab vs. placebo
COVID-19 severe or critically
NCT04317040, 0 NCT04317040
CD24Fc vs. placebo
COVID-19 severe or critically
ACTIV-1 cenicriviroc, 2020 NCT04593940
cenicriviroc vs. placebo
COVID-19 severe or critically
NCT04343989, 0 NCT04343989
clazakizumab vs. placebo
COVID-19 severe or critically
COLCHIVID, 2021 NCT04367168
colchicine vs. placebo
COVID-19 severe or critically
Brunetti, 2020
colchicine vs. standard of care
COVID-19 severe or critically
FORCE , 0 NCT04371367
complement inhibitors vs. standard of care
COVID-19 severe or critically
Duan, 2020
convalescent plasma treatment vs. control
COVID-19 severe or critically
Sean, 2020
convalescent plasma treatment vs. control
COVID-19 severe or critically
Hegerova, 2020
convalescent plasma treatment vs. control
COVID-19 severe or critically
Joyner, 2020 NCT04338360
convalescent plasma treatment vs. convalescent plasma treatment
COVID-19 severe or critically
Gonzales, 2021 NCT04381858
convalescent plasma treatment vs. immunoglobulin therapy
COVID-19 severe or critically
ILBS-COVID-02 (Bajpai M), 2020 NCT04346446
convalescent plasma treatment vs. placebo
COVID-19 severe or critically
O’Donnell, 2021 NCT04359810
convalescent plasma treatment vs. placebo
COVID-19 severe or critically
NCT04400058, 0 NCT04400058
convalescent plasma treatment vs. placebo
COVID-19 severe or critically
PlasmAr, 2020 NCT04344535
convalescent plasma treatment vs. placebo
COVID-19 severe or critically
PLASM-AR, 0 NCT04383535
convalescent plasma treatment vs. placebo
COVID-19 severe or critically
ChiCTR2000030627, 0 ChiCTR2000030627
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
CP-COVID-19, 2021 NCT04332835
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Li, 2020 ChiCTR2000029757
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Rasheed, 2020
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
COV2-CP, 0 NCT04385043
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
CAPSID, 2021 NCT04433910
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
AlQahtani, 2020 NCT04356534
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
REMAP-CAP (plasma), 2021 NCT02735707
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
RECOVER, 2021 EudCT 2020-001632-10
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
PICP19 (Ray), 2020 CTRI/2020/05/025209
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Bihariesingh-Sanchit (SuriCovid), 2021 ISRCTN18304314
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Pouladzadeh, 2021 IRCT20200310046736N1
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Sekine (PLACOVID), 2021 NCT04547660
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Ray, 2022
convalescent plasma treatment vs. standard of care
COVID-19 severe or critically
Lu, 2020
corticosteroids vs. control
COVID-19 severe or critically
Tomasz, 2020
corticosteroids vs. control
COVID-19 severe or critically
Salton (Methylprednisolone), 2020
corticosteroids vs. control
COVID-19 severe or critically
Monreal, 2020
corticosteroids vs. corticosteroids
COVID-19 severe or critically
ChiCTR2000029386, 0 ChiCTR2000029386
corticosteroids vs. standard of care
COVID-19 severe or critically
CODEX, 2020 NCT04327401
corticosteroids vs. standard of care
COVID-19 severe or critically
CORTICOVIDHUGO, 0 NCT04359511
corticosteroids vs. standard of care
COVID-19 severe or critically
Raef, 2020
corticosteroids vs. standard of care
COVID-19 severe or critically
Jianfeng, 2020
corticosteroids vs. standard of care
COVID-19 severe or critically
DEXA-COVID19, 2020 NCT04325061
dexamethasone vs. standard of care
COVID-19 severe or critically
CODEX (Tomazini), 2020 NCT04327401
dexamethasone vs. standard of care
COVID-19 severe or critically
Jamaati, 2021 IRCT20151227025726N1
dexamethasone vs. standard of care
COVID-19 severe or critically
Rashad, 2021 NCT04519385
dexamethasone vs. tocilizumab
COVID-19 severe or critically
Naik, 2021
dexamethasone vs. tocilizumab
COVID-19 severe or critically
COVID STEROID 2, 2021 NCT04509973
Dexamethasone 12mg vs. dexamethasone 6mg
COVID-19 severe or critically
CORIMUNO19-ECU, 0 NCT04346797
eculizumab vs. standard of care
COVID-19 severe or critically
Lopardo, 2021 NCT04494984
equine polyclonal antibodies INM005 vs. placebo
COVID-19 severe or critically
CAPE-COVID, 2020 NCT02517489
Hydrocortisone vs. placebo
COVID-19 severe or critically
Munch (COVID-STEROID), 2021 NCT04348305
Hydrocortisone vs. placebo
COVID-19 severe or critically
REMAP-CAP, fixed 7-day course, 2020 NCT02735707
Hydrocortisone vs. standard of care
COVID-19 severe or critically
REMAP-CAP, shock-dependent course, 2020 NCT02735707
Hydrocortisone vs. standard of care
COVID-19 severe or critically
Kalil (ACTT-3), 2021 NCT04492475
IFN beta-1a vs. placebo
COVID-19 severe or critically
Davoudi-Monfared, 2020 IRCT20100228003449N2
IFN beta-1a vs. standard of care
COVID-19 severe or critically
Darazam (COVIFERON Interferon beta-1a), 2021 NCT04343768
IFN beta-1a vs. standard of care
COVID-19 severe or critically
Rahmani, 2020 IRCT20100228003449N2
IFN beta-1b vs. standard of care
COVID-19 severe or critically
Darazam (COVIFERON Interferon beta-1b), 2021 NCT04343768
IFN beta-1b vs. standard of care
COVID-19 severe or critically
COUNTER-COVID, 0 2020-001236-10
imatinib vs. placebo
COVID-19 severe or critically
Aman, 2021 Eudra 2020–001236–10
imatinib vs. placebo
COVID-19 severe or critically
Gharebaghi, 2020 IRCT20200501047259N1
immunoglobulin therapy vs. placebo
COVID-19 severe or critically
Tabarsi, 2020 IRCT20151227025726N2
immunoglobulin therapy vs. standard of care
COVID-19 severe or critically
Raman, 2021 CTRI/2020/06/026222
immunoglobulin therapy vs. standard of care
COVID-19 severe or critically
ACTIV-1 infliximab, 0 NCT04593940
infliximab vs. placebo
COVID-19 severe or critically
Kumar, 2021 CTRI/2020/05/024959
itolizumab vs. standard of care
COVID-19 severe or critically
V.Lomakin (CORONA), 2021 NCT04397562
Levilimab vs. placebo
COVID-19 severe or critically
NCT04447469, 0 NCT04447469
mavrilimumab vs. placebo
COVID-19 severe or critically
Farahani, 2020 IRCT20200406046963N1
methylprednisolone vs. control
COVID-19 severe or critically
Steroids-SARI, 2020 NCT04244591
methylprednisolone vs. standard of care
COVID-19 severe or critically
Edalatifard, 2020 IRCT20200404046947N1
methylprednisolone vs. standard of care
COVID-19 severe or critically
Belhassen-Garc??a, 2021
methylprednisolone vs. tocilizumab
COVID-19 severe or critically
ENACOVID, 0 NCT04325633
naproxen, ibuprofen vs. standard of care
COVID-19 severe or critically
LIBA, 0 NCT04334629
naproxen, ibuprofen vs. standard of care
COVID-19 severe or critically
RUXCOVID, 0 NCT04362137
ruxolitinib vs. placebo
COVID-19 severe or critically
DEVENT, 0 NCT04377620
ruxolitinib vs. placebo
COVID-19 severe or critically
Cao, 2020
ruxolitinib vs. vitamin C
COVID-19 severe or critically
SARPAC, 0 NCT04326920
sargramostim vs. standard of care
COVID-19 severe or critically
sarilumab Sanofi phase 3 US, 0 NCT04315298
sarilumab vs. control
COVID-19 severe or critically
ARI-RAF (Della-Torre), 2020
sarilumab vs. control
COVID-19 severe or critically
sarilumab Sanofi phase 3 outside US, 0
sarilumab vs. placebo
COVID-19 severe or critically
REMAP-CAP sarilumab, 2021 NCT02735707
sarilumab vs. standard of care
COVID-19 severe or critically
CORIMUNO-VIRO, 0 NCT04341870
sarilumab azithromycin hydroxychloroquine vs. sarilumab
COVID-19 severe or critically
Lescure (Sarilumab 400mg), 2021 NCT04327388
sarilumab high dose (400mg) vs. placebo
COVID-19 severe or critically
Lescure (Sarilumab 200mg), 2021 NCT04327388
sarilumab low dose (200mg) vs. placebo
COVID-19 severe or critically
INSPIRATION-S), 0
statins vs. control
COVID-19 severe or critically
STROMA-CoV2, 0 NCT04333368
stem cells vs. placebo
COVID-19 severe or critically
Shi, 2020 NCT04288102
stem cells vs. placebo
COVID-19 severe or critically
NCT04336254, 2020 NCT04336254
stem cells vs. standard of care
COVID-19 severe or critically
Shu, 2020 ChiCTR2000031494
stem cells vs. standard of care
COVID-19 severe or critically
TACROVID, 2021 NCT04341038
tacrolimus vs. standard of care
COVID-19 severe or critically
Singh (TD-0903 10mg), 2021 NCT04402866
TD-0903 10mg vs. placebo
COVID-19 severe or critically
Singh (TD-0903 1mg), 2021 NCT04402866
TD-0903 1mg vs. placebo
COVID-19 severe or critically
Singh (TD-0903 3mg), 2021 NCT04402866
TD-0903 3mg vs. placebo
COVID-19 severe or critically
Amra, 2021 IRCT20170207032444N3
thalidomide vs. standard of care
COVID-19 severe or critically
ChiCTR2000029806 (thymosin), 0 ChiCTR2000029806
thymosin vs. standard of care
COVID-19 severe or critically
Karakike (ESCAPE), 2021 NCT04339712
tocilizumab vs. anakinra
COVID-19 severe or critically
TOCI-RAF Study Group (Campochiaro), 2020
tocilizumab vs. control
COVID-19 severe or critically
Somers, 2020
tocilizumab vs. control
COVID-19 severe or critically
Mathilde, 2020
tocilizumab vs. control
COVID-19 severe or critically
Andrew, 2020
tocilizumab vs. control
COVID-19 severe or critically
Biran, 2020
tocilizumab vs. control
COVID-19 severe or critically
Klopfenstein, 2020
tocilizumab vs. control
COVID-19 severe or critically
Rashad, 2021 NCT04519385
tocilizumab vs. dexamethasone
COVID-19 severe or critically
CORON-ACT, 0 NCT04335071
tocilizumab vs. placebo
COVID-19 severe or critically
COVACTA (Rosas), 2020 NCT04320615
tocilizumab vs. placebo
COVID-19 severe or critically
NCT04377750 (HMO-0224-20), 0 NCT04377750
tocilizumab vs. placebo
COVID-19 severe or critically
Rosas (REMDACTA), 2021 NCT04409262
tocilizumab vs. placebo
COVID-19 severe or critically
Sarhan, 2022 NCT04779047
tocilizumab vs. remdesivir
COVID-19 severe or critically
ChiCTR2000030580, 0 ChiCTR2000030580
tocilizumab vs. standard of care
COVID-19 severe or critically
Rojas-Marte, 2020
tocilizumab vs. standard of care
COVID-19 severe or critically
Pereira, 2020
tocilizumab vs. standard of care
COVID-19 severe or critically
CORIMUNO-TOCI-1 (Group 1), 2020 NCT04331808
tocilizumab vs. standard of care
COVID-19 severe or critically
REMAP-CAP (tocilizumab), 2021 NCT02735707
tocilizumab vs. standard of care
COVID-19 severe or critically
Veiga, 2021 NCT04403685
tocilizumab vs. standard of care
COVID-19 severe or critically
Talaschian, 2021 IRCT20081027001411N4
tocilizumab vs. standard of care
COVID-19 severe or critically
Hamed, 2021
tocilizumab vs. standard of care
COVID-19 severe or critically
Karampitsakos, 2021
tocilizumab vs. standard of care
COVID-19 severe or critically
CORIMUNO-TOCI-ICU (Group 2), 2020 NCT04331808
tocilizumab vs. standard of care
COVID-19 severe or critically
MARIPOSA, 2021 NCT04363736
tocilizumab vs. tocilizumab
COVID-19 severe or critically
Belhassen-Garc??a, 2021
tocilizumab vs. tocilizumab
COVID-19 severe or critically
Sarhan, 2022 NCT04779047
tocilizumab vs. tocilizumab
COVID-19 severe or critically
PANAMO, 0 NCT04333420
vilobelimab (IFX-1) vs. standard of care
COVID-19 severe or critically
