| 4830 | NCT04276896, 0 | 2 | 30 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 6966 | Ou, 2021 | 2 | 32 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 7070 | PHE variants (Technical briefing 12 22 may 2021), 2021 | 2 | 20 | 2 | excluded | not a RCT | |
| 7420 | PHE (Stowe), 2021 | 2 | 13 | 3 | excluded | not a RCT | high risk of bias |
| 8149 | PHE Technical briefing 16 (11/18 June 2021), 2021 | 2 | 13 | 3 | excluded | not a RCT | high risk of bias |
| 8248 | Montgomery, 2021 | 2 | 13 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 8275 | Musser, 2021 | 2 | 13 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 8350 | Rosenberg, 2021 | 2 | 13 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 8515 | Scobie, 2021 | 2 | 20 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9065 | Ruddy, 2021 | 2 | 32 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9129 | COV-BOOST, 2021 | 2 | 1 | 0 | excluded | risk of bias not avaialble | |
| 9130 | Gilboa, 2021 | 2 | 0 | 0 | excluded | risk of bias not avaialble | |
| 9170 | UKHSA report 33 (23 december 2021), 2021 | 2 | 20 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9176 | UKHSA 31 december 2021, 2021 | 2 | 20 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9178 | Liu, 2021 | 2 | 1 | 0 | excluded | risk of bias not avaialble | |
| 9214 | Southern California (Lewnard), 2022 | 2 | 13 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9240 | Chen, 2021 | 2 | 1 | 0 | excluded | risk of bias not avaialble | |
| 9275 | Mattiuzzi, 2022 | 2 | 0 | 0 | excluded | risk of bias not avaialble | |
| 9290 | Danza, 2022 | 2 | 32 | 0 | excluded | not a RCT | risk of bias not avaialble |
| 9294 | UKHSA (report W4- 27 January), 2022 | 2 | 12 | 0 | excluded | not a RCT | risk of bias not avaialble |
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