potential COVID-19 treatments living meta-analysis of clinical studies

	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically

	COVID 19 hospitalized	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically
potential COVID-19 treatments
adjuvant therapies
anticoagulant	Paranjpe		X-COVID-19
anticoagulant, curative dose	Bousquet Bousquet COALIZAO ACTION		ATTACC, ACTIV-4a, and REMAP-CAP ...	REMAP-CAP, ACTIV-4a, ATTACC ... COVID-PACT
anticoagulant, prophylactic dose	Bousquet Bousquet			Tang
anticoagulation, intermediate prophylactic dose				INSPIRATION
heparin at therapeutic dose			RAPID ...	ATTACC ... ACTIV-4a ... REMAP-CAP Anticoagulation
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies	Malgorzata
anti GM-CSF
mavrilimumab	MASH-COVID ...
clarithromycine	Tsiakos		Rashad ...
colchicine	COLCOVID Scarsi Lopes MIF Salehzadeh GRECCO-19 RECOVERY ... Horby Sandhu		COL-COVID ...	COLCHIVID Brunetti
Colchicine plus rosuvastatin	COLSTAT Gaitan-Duarte ...
non-steroidal anti-inflammatory drugs	Jeong Bruce Imam Drake		Guzman-Esquivel
Celecoxib	Wenxin
Indomethacin			Ravichandran Ravichandran
stem cells	Lanzoni Carmenate ...			Shu Shi
vilobelimab (IFX-1)				PANAMO
corticosteroids	Fernández Cruz GLUCOCOVID Rahman Albani SAM-COVID-19 Rodriguez-Bano ... Rodriguez-Bano ...		Li ... Majmundar	Lu Raef Jianfeng Tomasz Salton ... Monreal
dexamethasone	RECOVERY dexamethasone			DEXA-COVID19 CODEX ... Jamaati Rashad Naik
Dexamethasone 12mg				COVID STEROID 2
Hydrocortisone				CAPE-COVID REMAP-CAP, fixed 7-day course REMAP-CAP, shock-dependent course Munch ...
methylprednisolone	Tang X Metcovid Ranjbar			Steroids-SARI Edalatifard Farahani Belhassen-Garc??a
Immunostimulants drugs
convalescent plasma treatment	ConCOVID ... Abolghasemi Salazar ConPlas-19 COP-COVID-19 CONTAIN COVID-19 PC/COVID-19 NCT04397757 PLACO-COVID CONCOR-1 CPC-SARS NCT04442191 DAWN-Plasma NCT04385199 COPLA-II trial NCT04403477 ... ASCOT RECOVERY ... CONFIDENT PERUCONPLASMA Bennett-Guerrero Salman Kirenga LACCPT Co-CLARITY NCT04528368 Holm K CCAP-2 Baldeon Menichetti	LIFESAVER	PLACID Libster	CP-COVID-19 ILBS-COVID-02 ... Duan Li Sean Rasheed Hegerova O’Donnell PlasmAr CAPSID AlQahtani Joyner REMAP-CAP ... RECOVER PICP19 ... Bihariesingh-Sanchit ... Pouladzadeh Sekine ... Ray
Early convalescent plasma.	Balcells
immunoglobulin therapy	Sakoulas Parikh			Tabarsi Gharebaghi Raman
interferon	Wang ... Wang	Cai -FAVIPIRAVIR Cai -FAVIPIRAVIR
IFN beta-1a	SOLIDARITY ...			Davoudi-Monfared Darazam ... Kalil ...
high-dose IFN beta-1a	Darazam
IFN beta-1b				Rahmani Darazam ...
IFN gamma	Esquivel-Moynelo
inhaled interferon
IFN alpha
pegylated interferon-α2b			Pandit Shashi Bhushan
recombinant super-compound interferon rSIFN-co	Li
SNG001 inhaled interferon beta	Synairgen SG016 SPRINTER
interferon / TFF2			Fu
peginterferon			Jagannathan
PNB001			Lattmann
neutralizing antibody	ITAC
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences)	ACTIV-3 ...
bamlanivimab monotherapy	ACTIV-3/TICO LY-CoV555
casirivimab/imdevimab (Ronapreve)	RECOVERY ...		Somersan-Karakaya ... Suzuki
cilgavimab and tixagevimab (Evusheld)	ACTIV-3/TICO ...	Chen
equine polyclonal antibodies INM005				Lopardo
sotrovimab (Xevudy; VIR-7831)	ACTIV-3/ TICO ...
Immunosuppressants drugs
abatacept				ACTIV-1 abatacept
adalimumab				Fakharian
anakinra	SAVE-MORE		CORIMUNO-ANA-1	Ana-COVID ... Kooistra
anti-interleukin-6
Levilimab				V.Lomakin ...
sarilumab	CORIMUNO-SARI-1 ...			sarilumab Sanofi phase 3 US ARI-RAF ... sarilumab Sanofi phase 3 outside US REMAP-CAP sarilumab
sarilumab high dose (400mg)		sarilumab phase 2 high dose		Lescure ...
sarilumab low dose (200mg)		sarimulab phase 2 low dose		Lescure ...
tocilizumab	Dongsheng Wang RCT-TCZ-COVID-19 Martinez-Sanz HNF Hospital Tocilizumab multidisciplinary team Colaneri EMPACTA Tsai SAM-COVID-19 RECOVERY Soin AS ... Rutgers NCT04412772 ... Declercq J ... NCT04577534 ... EU-CTR2020-001375-32 ... EU-CTR2020-001748-24 ... NCT04479358 ... NCT04434717 ...	TOCOVID BACC Bay Tocilizumab Trial	Capra	TOCI-RAF Study Group ... Rojas-Marte Somers Mathilde Andrew MARIPOSA Biran COVACTA ... Pereira CORIMUNO-TOCI-1 ... REMAP-CAP ... Veiga Rashad Talaschian Hamed Karampitsakos CORIMUNO-TOCI-ICU ... NCT04377750 ... Rosas ... Karakike ... Belhassen-Garc??a Sarhan Sarhan
canakinumab	Sheng ...			CAN-COVID
cenicriviroc				ACTIV-1 cenicriviroc
infliximab				ACTIV-1 infliximab
itolizumab				Kumar
janus kinase (JAK) inhibitor
baricitinib	COV-BARRIER ACTT-2 ...	RECOVERY	Rodriguez-Garcia Cantini	Tziolos COV-BARRIER ...
ruxolitinib				Cao DEVENT
TD-0903
TD-0903 10mg				Singh ...
TD-0903 1mg				Singh ...
TD-0903 3mg				Singh ...
tofacitinib	STOP-COVID ...		Murugesan
lenzilumab			LIVE-AIR ...
tacrolimus				TACROVID
thalidomide				Amra
Kinase inhibitors
acalabrutinib	CALAVI CALAVI US
imatinib			Covid-19 HUF	Aman
leflunomide	Wang et al.	Wang
statins
Atorvastatin				INSPIRATION-S
antiandrogenic
progesterone			Ghandehari
proxalutamide	Cadegiani
antiviral and associated therapy
azithromycin	Rosenberg Sekhavati Rodriguez-Molinero RECOVERY ...		COALITION I Covid-19 Brazil ... Espitia-Hernandez Rashad A ...	COALITION II Covid-19 Brazil ...
azvudine			Ren
baloxavir marboxil	Lou Y
bromhexine	Ansarin Tolouian		Li T
chloroquine and derivatives	Rosenberg			Karolyi
chloroquine	Chen_chloroquine Huang Huang	Chen, ChiCTR2000030054 - Chloroquine	NCT04342650
hydroxychloroquine	Tang HAHPS ORCHID Duke University hydroxychloroquine/azithromycine Magagnoli ... Geleris Novales RECOVERY Paccoud Sbidian ... SOLIDARITY ... Arshad ... Chen NO COVID-19 ... Kalligeros Belgian Collaborative Group on COVID-19 Abd-Elsalam Cravedi Fontana Singh CCAP-1 Duke university HCQ ARCHAIC -hydroxychloroquine PROTECT B TEACH OAHU-COVID19 HYCOVID IRCT20200428047228N1 // U07 Gonzalez ... PROTECT A	Gautret et al. ChiCTR2000030054-HCQ ... IRCT20150808023559N20 IRCT20150808023559N20 NCT04376814-Group A NCT04376814-Group A NOR-Solidarity ...	HC-nCoV ... Zhaowei Chen Coalition Covid-19 Brazil I ... Min NCT04333654 FACCT Trial Dubee Kamran	Mahevas Yu REMAP-CAP-HCQ HYDRA ... Sarhan Sarhan
darunavir cobicistat		Jun C
doxycycline	Spoorthi		Spoorthi
Emtricitabine/tenofovir plus colchicine plus rosuvastatin	Gaitan-Duarte ...
Ensitrelvir (XOCOVA)			Mukae - Phase 2a
favipiravir	IRCT20200428047228N1 // U07 Udwadia AVIFAVIR	Cai -FAVIPIRAVIR Cai -FAVIPIRAVIR Lou ... Chang Chen et al. NCT04310228-FAVI ... jRCTs041190120 IRCT20150808023559N20 IRCT20150808023559N20 NCT04376814-Group A NCT04376814-Group A Calik	Dabbous HM Holubar M IRCT20151227025726N14 // U07 FACCT Trial Udwadia AVIFAVIR Shenoy S NCT04542694 Ruzhentsova T Solaymani-Dodaran Shinkai	Kocayigit H
favipiravir plus interferon			Khamis
hydroxychloroquine plus macrolides	Rosenberg Carlucci Sbidian ... Lagier Arshad ... Davido Duke university HCQ-AZI	Magagnoli ...		Huang
azithromycin plus hydroxychloroquine	ProPAC-COVID		Coalition Covid-19 Brazil I ...
ivermectin	ICON Khan Soto-Becerra Spoorthi Gonzalez ...		Glorial F Shahbaznejad Ahmed Chachar Chaccour Espitia-Hernandez Khan Soto-Becerra Spoorthi Bukhari Kirti Babalola RIVET-COV ... Abd-Elsalam Krolewiecki I-TECH ... Mayer	Camprubi Okumuş Galan Galan
ivermectin plus doxycycline	Hashim A		NCT04523831 ...
lopinavir/ritonavir	RECOVERY SOLIDARITY ... Nojomi Chen_lopi_rito Ader ...		ELACOI ...	Cao REMAP-CAP ...
Lopinavir/ritonavir plus hydroxychloroquine				REMAP-CAP ...
lopinavir/ritonavir plus interferon ß-1a	Ader ...
lopinavir/ritonavir, ribavirin and interferon beta-1b			Hung et al.
niclosamide	Abdulamir
nirmatrelvir / ritonavir (Paxlovid)		EPIC-SR
nitazoxanide			Rocco Silva Fontanesi
opaganib	Winthrop
oseltamivir	Chen_oseltamivir
remdesivir	NIH NIAID ACTT-1 DisCoVeRy ... remdesevir external control SOLIDARITY ... Mahajan	Norwegian NOR study ... Andreas ...	GS-US-540-5774, 10 days GS-US-540-5774, 5 days GS-US-540-5773 ...	CAP-China ...
sofosbuvir	Sali Alavi-moghaddam
sofosbuvir and daclatasvir	Sadeghi Yakoot Mobarak S ... Mobarak ...			Eslami
sofosbuvir and ledipasvir	Elgohary		Nourian A
tenofovir/emtricitabine	Gaitan-Duarte ...
umifenovir (arbidol)	UAIIC Nojomi Chen_arbidol	ELACOI ...	Yethindra ELACOI ...
zinc	Patel
Drugs for acid related disorders
H2 blockers
famotidine	Samimagham
proton pump inhibitors (PPI)	Argenziano Ramachandran Zhang
miscellaneous
alpha lipoic acid				Ming Zhong
Aspirin	RECOVERY ...
aviptadil		COVID-AIV		ACTIV-3 Critical Care
camostat mesilate		Gunst JD
Cannabidiol			Crippa ...
honey	Silveira
povidone-iodine	Mohamed
pyridostigmine				Fragoso-Saavedra ...
sabizabulin			VERU-111
Oral antidiabetic drugs
dapagliflozin	DARE-19
DPP-4 inhibitor	CORONADO Guardado-Mendoza	Rhee ... Noh Rhee ...		Abuhasira
Renin-angiotensin-system-acting agents		Yang Bean Zhang Li Meng Yan et al.
angiotensin receptor blockers (ARBs)	Duarte Nouri-Vaskeh
losartan		University of Minnesota
discontinuation of ACEI/ARB	REPLACE Najmeddin		Lopes ...
Vitamins
vitamin C				Zhang Jamali Moghadam Siahkali Kumari
Vitamin D	Entrenas ... Murai Annweiler ... Annweiler ...		Rastogi Espitia-Hernandez	COVID-VIT-D
hight dose vitamin D			COVIT-TRIAL

1 studies excluded by filtering options 2