anti-inflammatoty and immuno-therapy living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID 19 hospitalized
	COVID-19 severe or critically
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
colchicine	COLCHIVID
stem cells	Shu Shi
vilobelimab (IFX-1)	PANAMO
corticosteroids
dexamethasone	DEXA-COVID19 CODEX ... Jamaati Rashad Naik
Dexamethasone 12mg	COVID STEROID 2
Hydrocortisone	CAPE-COVID REMAP-CAP, fixed 7-day course REMAP-CAP, shock-dependent course Munch ...
methylprednisolone	Steroids-SARI Edalatifard Farahani
Immunostimulants drugs
convalescent plasma treatment	CP-COVID-19 ILBS-COVID-02 ... Li Rasheed O’Donnell PlasmAr CAPSID AlQahtani REMAP-CAP ... RECOVER PICP19 ... Pouladzadeh Sekine ... Ray
immunoglobulin therapy	Tabarsi Gharebaghi Raman
interferon
IFN beta-1a	Davoudi-Monfared Darazam ... Kalil ...
IFN beta-1b	Rahmani Darazam ...
neutralizing antibody
equine polyclonal antibodies INM005	Lopardo
Immunosuppressants drugs
abatacept	ACTIV-1 abatacept
adalimumab	Fakharian
anti-interleukin-6
Levilimab	V.Lomakin ...
sarilumab	sarilumab Sanofi phase 3 US sarilumab Sanofi phase 3 outside US REMAP-CAP sarilumab
sarilumab high dose (400mg)	Lescure ...
sarilumab low dose (200mg)	Lescure ...
tocilizumab	MARIPOSA COVACTA ... CORIMUNO-TOCI-1 ... REMAP-CAP ... Veiga Rashad Talaschian Hamed CORIMUNO-TOCI-ICU ... NCT04377750 ... Rosas ... Sarhan Sarhan
canakinumab	CAN-COVID
cenicriviroc	ACTIV-1 cenicriviroc
infliximab	ACTIV-1 infliximab
itolizumab	Kumar
janus kinase (JAK) inhibitor
baricitinib	COV-BARRIER ...
ruxolitinib	Cao DEVENT
TD-0903
TD-0903 10mg	Singh ...
TD-0903 1mg	Singh ...
TD-0903 3mg	Singh ...
tacrolimus	TACROVID
thalidomide	Amra
Kinase inhibitors
imatinib	Aman
statins
Atorvastatin	INSPIRATION-S

25 studies excluded by filtering options 3

4930	Huijie Bian, 2020	2	31	3	excluded	not a RCT	high risk of bias
5317	Lu, 2020	1	22	3		not a RCT	high risk of bias
5319	Wu, 2020	1	13	3		not a RCT	high risk of bias
5453	Raef, 2020	1	13	4		not a RCT	high risk of bias
5454	Jianfeng, 2020	1	13	3		not a RCT	high risk of bias
5455	Tomasz, 2020	1	20	4		not a RCT	high risk of bias
5456	Fernández Cruz, 2020	1	13	3		not a RCT	high risk of bias
5476	Yuan, 2020	0	13	0	selection pending
5484	Salton (Methylprednisolone), 2020	0	13	4	selection pending
5485	openSafely, 2020	0	13	0	selection pending
5510	Malgorzata, 2020	1	13	4		not a RCT	high risk of bias
5552	Rahman, 2020	0	13	0	selection pending
5568	Zhang, 2020	0	13	0	selection pending
5603	Albani, 2020	0	13	0	selection pending
5612	Bernaola, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5614	Monreal, 2020	0	13	0	selection pending
5615	Nelson (Methylprednisolone), 2020	0	13	0	selection pending
5639	Li (Methylprednisolone, Shanghai cohort), 2020	0	13	0	selection pending
5796	SAM-COVID-19, 2020	0	13	0	selection pending
5840	Majmundar, 2020	0	13	0	selection pending
5939	Li (Methylprednisolone, Validation cohort), 2020	0	13	0	selection pending
5952	Rodriguez-Bano (intermediate-high dose CS), 2020	0	13	0	selection pending
5953	Rodriguez-Bano (CS pulse dose), 2020	0	13	0	selection pending
6036	Esba, 2020	0	10	0	selection pending
6048	Wu, 2020	0	11	0	selection pending