chloroquine and derivatives living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only observational study

	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically

	COVID 19 hospitalized	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically
chloroquine and derivatives	Rosenberg			Karolyi
chloroquine	Chen_chloroquine Huang Huang	Chen, ChiCTR2000030054 - Chloroquine	NCT04342650
hydroxychloroquine	RECOVERY Kalligeros Duke university HCQ HYCOVID Magagnoli ... Paccoud ARCHAIC -hydroxychloroquine Gonzalez ... Sbidian ... Belgian Collaborative Group on COVID-19 Geleris SOLIDARITY ... Abd-Elsalam PROTECT A HAHPS Arshad ... Cravedi PROTECT B ORCHID Fontana TEACH Duke University hydroxychloroquine/azithromycine Novales Chen Singh OAHU-COVID19 Tang NO COVID-19 ... CCAP-1 IRCT20200428047228N1 // U07	Gautret et al. ChiCTR2000030054-HCQ ... IRCT20150808023559N20 IRCT20150808023559N20 NCT04376814-Group A NCT04376814-Group A NOR-Solidarity ...	Zhaowei Chen Dubee Coalition Covid-19 Brazil I ... NCT04333654 Kamran Min HC-nCoV ... FACCT Trial	HYDRA ... Yu Sarhan Mahevas REMAP-CAP-HCQ Sarhan

4899	ChiCTR2000029826 (Cancelled by the investigator), 0	2	1	0	excluded		risk of bias not avaialble
4905	ChiCTR2000029975, 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
4987	CloroCOVID19, 2020	2	1	3	excluded		high risk of bias
5226	Duke university (Hydroxychloroquine), 2020	2	1	0	excluded		risk of bias not avaialble
5288	Barbosa, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5351	Mallat, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5864	HYDRA, 2020	2	1	0	excluded		risk of bias not avaialble
6697	Thakar, 2021	2	1	0	excluded		risk of bias not avaialble