anti-inflammatoty and immuno-therapy living meta-analysis of clinical studies

	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically

	COVID 19 hospitalized	COVID 19 all comers	COVID-19 mild to moderate	COVID-19 severe or critically
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies	Malgorzata
anti GM-CSF
mavrilimumab	MASH-COVID ...
clarithromycine	Tsiakos		Rashad ...
colchicine	COLCOVID Scarsi Lopes MIF Salehzadeh GRECCO-19 RECOVERY ... Horby Sandhu		COL-COVID ...	COLCHIVID Brunetti
Colchicine plus rosuvastatin	COLSTAT Gaitan-Duarte ...
non-steroidal anti-inflammatory drugs	Jeong Bruce Imam Drake		Guzman-Esquivel
Celecoxib	Wenxin
Indomethacin			Ravichandran Ravichandran
stem cells	Lanzoni Carmenate ...			Shu Shi
vilobelimab (IFX-1)				PANAMO
corticosteroids	Fernández Cruz GLUCOCOVID Rahman Albani SAM-COVID-19 Rodriguez-Bano ... Rodriguez-Bano ...		Li ... Majmundar	Lu Raef Jianfeng Tomasz Salton ... Monreal
dexamethasone	RECOVERY dexamethasone			DEXA-COVID19 CODEX ... Jamaati Rashad Naik
Dexamethasone 12mg				COVID STEROID 2
Hydrocortisone				CAPE-COVID REMAP-CAP, fixed 7-day course REMAP-CAP, shock-dependent course Munch ...
methylprednisolone	Tang X Metcovid Ranjbar			Steroids-SARI Edalatifard Farahani Belhassen-Garc??a
Immunostimulants drugs
convalescent plasma treatment	ConCOVID ... Abolghasemi Salazar ConPlas-19 COP-COVID-19 CONTAIN COVID-19 PC/COVID-19 NCT04397757 PLACO-COVID CONCOR-1 CPC-SARS NCT04442191 DAWN-Plasma NCT04385199 COPLA-II trial NCT04403477 ... ASCOT RECOVERY ... CONFIDENT PERUCONPLASMA Bennett-Guerrero Salman Kirenga LACCPT Co-CLARITY NCT04528368 Holm K CCAP-2 Baldeon Menichetti	LIFESAVER	PLACID Libster	CP-COVID-19 ILBS-COVID-02 ... Duan Li Sean Rasheed Hegerova O’Donnell PlasmAr CAPSID AlQahtani Joyner REMAP-CAP ... RECOVER PICP19 ... Bihariesingh-Sanchit ... Pouladzadeh Sekine ... Ray
Early convalescent plasma.	Balcells
immunoglobulin therapy	Sakoulas Parikh			Tabarsi Gharebaghi Raman
interferon	Wang ... Wang	Cai -FAVIPIRAVIR Cai -FAVIPIRAVIR
IFN beta-1a	SOLIDARITY ...			Davoudi-Monfared Darazam ... Kalil ...
high-dose IFN beta-1a	Darazam
IFN beta-1b				Rahmani Darazam ...
IFN gamma	Esquivel-Moynelo
inhaled interferon
IFN alpha
pegylated interferon-α2b			Pandit Shashi Bhushan
recombinant super-compound interferon rSIFN-co	Li
SNG001 inhaled interferon beta	Synairgen SG016 SPRINTER
interferon / TFF2			Fu
peginterferon			Jagannathan
PNB001			Lattmann
neutralizing antibody	ITAC
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences)	ACTIV-3 ...
bamlanivimab monotherapy	ACTIV-3/TICO LY-CoV555
casirivimab/imdevimab (Ronapreve)	RECOVERY ...		Somersan-Karakaya ... Suzuki
cilgavimab and tixagevimab (Evusheld)	ACTIV-3/TICO ...	Chen
equine polyclonal antibodies INM005				Lopardo
sotrovimab (Xevudy; VIR-7831)	ACTIV-3/ TICO ...
Immunosuppressants drugs
abatacept				ACTIV-1 abatacept
adalimumab				Fakharian
anakinra	SAVE-MORE		CORIMUNO-ANA-1	Ana-COVID ... Kooistra
anti-interleukin-6
Levilimab				V.Lomakin ...
sarilumab	CORIMUNO-SARI-1 ...			sarilumab Sanofi phase 3 US ARI-RAF ... sarilumab Sanofi phase 3 outside US REMAP-CAP sarilumab
sarilumab high dose (400mg)		sarilumab phase 2 high dose		Lescure ...
sarilumab low dose (200mg)		sarimulab phase 2 low dose		Lescure ...
tocilizumab	Dongsheng Wang RCT-TCZ-COVID-19 Martinez-Sanz HNF Hospital Tocilizumab multidisciplinary team Colaneri EMPACTA Tsai SAM-COVID-19 RECOVERY Soin AS ... Rutgers NCT04412772 ... Declercq J ... NCT04577534 ... EU-CTR2020-001375-32 ... EU-CTR2020-001748-24 ... NCT04479358 ... NCT04434717 ...	TOCOVID BACC Bay Tocilizumab Trial	Capra	TOCI-RAF Study Group ... Rojas-Marte Somers Mathilde Andrew MARIPOSA Biran COVACTA ... Pereira CORIMUNO-TOCI-1 ... REMAP-CAP ... Veiga Rashad Talaschian Hamed Karampitsakos CORIMUNO-TOCI-ICU ... NCT04377750 ... Rosas ... Karakike ... Belhassen-Garc??a Sarhan Sarhan
canakinumab	Sheng ...			CAN-COVID
cenicriviroc				ACTIV-1 cenicriviroc
infliximab				ACTIV-1 infliximab
itolizumab				Kumar
janus kinase (JAK) inhibitor
baricitinib	COV-BARRIER ACTT-2 ...	RECOVERY	Rodriguez-Garcia Cantini	Tziolos COV-BARRIER ...
ruxolitinib				Cao DEVENT
TD-0903
TD-0903 10mg				Singh ...
TD-0903 1mg				Singh ...
TD-0903 3mg				Singh ...
tofacitinib	STOP-COVID ...		Murugesan
lenzilumab			LIVE-AIR ...
tacrolimus				TACROVID
thalidomide				Amra
Kinase inhibitors
acalabrutinib	CALAVI CALAVI US
imatinib			Covid-19 HUF	Aman
leflunomide	Wang et al.	Wang
statins
Atorvastatin				INSPIRATION-S

4930	Huijie Bian, 2020	2	31	3	excluded	not a RCT	high risk of bias
5612	Bernaola, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble

2 studies excluded by filtering options 2