antiviral and associated therapy living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID 19 outpatients
antiviral and associated therapy
azithromycin	Hinks ... PRINCIPLE ACTION
chloroquine and derivatives	ALBERTA HOPE-Covid19
hydroxychloroquine	COVID-PEP Severity ... Q-PROTECT -HCQ alone BCN PEP-CoV-2-Study 2 ... COMIHY Reis ... NCT04597775 PATCH Cohort 1 ... COPE – Coalition V
fluvoxamine	COVID-OUT ... TOGETHER ACTIV-6 Lenze ...
hydroxychloroquine plus macrolides	NCT04621461
azithromycin plus hydroxychloroquine	Q-PROTECT ... Q-PROTECT -AZI ... Rodrigues
ivermectin	ACTIV-6 ... Podder Chahla Chaccour TOGETHER ... Buonfrate ... IVERCORCOVID19 ... Lopez-Medina ACTIV 6 ivermectin COVID-OUT ...
ivermectin plus doxycycline	Chowdhury A
lopinavir/ritonavir	Reis ...
molnupiravir	Fischer ... MOVe-OUT
nirmatrelvir / ritonavir (Paxlovid)	EPIC-HR
nitazoxanide	RM08-3008 ...
remdesivir	PINETREE ...
sofosbuvir and daclatasvir	Roozbeh
umifenovir (arbidol)	Ramachandran
zinc	Thomas ...

70 studies excluded by filtering options 3

4861	Cai -FAVIPIRAVIR, 2020	1	31	0		not a RCT	risk of bias not avaialble
4905	ChiCTR2000029975, 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
5209	SIMPLE (Grein), 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
5210	Ye et al., 2020	2	99	0	excluded	not a RCT	risk of bias not avaialble
5288	Barbosa, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5314	Magagnoli (HC AZ), 2020	1	13	3		not a RCT	high risk of bias
5351	Mallat, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5365	Rosenberg, 2020	1	13	3		not a RCT	high risk of bias
5371	Carlucci, 2020	0	13	4	selection pending
5374	Million, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5375	Mehra, 2020	2	13	3	excluded	not a RCT	high risk of bias
5416	Guerin, 2020	2	31	4	excluded	not a RCT	high risk of bias
5416	Guerin, 2020	2	31	4	excluded	not a RCT	high risk of bias
5445	Nguyen, 2020	0	21	0	selection pending
5448	COVID-19 Global Rheumatology Alliance, 2020	0	13	0	selection pending
5470	Singh, 2020	0	21	0	selection pending
5471	Sarayani, 2020	0	21	0	selection pending
5482	Sbidian (HCQ plus AZI), 2020	1	13	4		not a RCT	high risk of bias
5490	Kurd, 2020	0	10	0	selection pending
5509	Lagier, 2020	1	13	4		not a RCT	high risk of bias
5513	Arshad (HCQ AZ), 2020	1	13	4		not a RCT	high risk of bias
5546	remdesevir external control, 0	0	13	0	selection pending
5559	Davido, 2020	1	13	4		not a RCT	high risk of bias
5599	Karolyi, 2020	0	13	0	selection pending
5611	Wang, 0	0	13	0	selection pending
5681	Lane, 2020	0	13	0	selection pending
6034	Huang, 2020	0	99	0	selection pending
6047	Hsia, 2020	0	99	0	selection pending
6064	Glorial F, 2020	1	10	0		not a RCT	risk of bias not avaialble
6080	IDEA, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6082	ICON, 2020	0	13	0	selection pending
6095	Camprubi, 2020	1	11	0		not a RCT	risk of bias not avaialble
6098	Patel, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6134	Morgenstern, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
6184	Erdem, 2020	2	11	0	excluded	not a RCT	risk of bias not avaialble
6252	NCT04376814-Group A, 2020	0	31	0	selection pending
6262	Yamamura, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
6263	Calik, 2020	1	10	4		not a RCT	high risk of bias
6267	Murohashi, 2020	2	10	0	excluded	not a RCT	risk of bias not avaialble
6287	Kocayigit H, 2020	1	10	0		not a RCT	risk of bias not avaialble
6332	Rodriguez-Molinero, 2020	1	10	0		not a RCT	risk of bias not avaialble
6339	Delliere, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
6372	Alam, 2020	0	31	3	selection pending
6373	Behera, 2020	1	20	0		not a RCT	risk of bias not avaialble
6374	NCT04425850 (Caravallo), 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6375	Cadegiani -Iver, 2020	2	99	0	excluded	not a RCT	risk of bias not avaialble
6379	Chamie-Quintero,, 2020	2	15	0	excluded	not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6381	Espitia-Hernandez, 2020	1	31	0		not a RCT	risk of bias not avaialble
6382	Khan, 2020	0	13	0	selection pending
6382	Khan, 2020	0	13	0	selection pending
6383	Soto-Becerra, 2020	0	12	2	selection pending
6383	Soto-Becerra, 2020	0	12	2	selection pending
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6384	Spoorthi, 2020	1	31	0		not a RCT	risk of bias not avaialble
6516	Eslami, 2020	1	31	0		not a RCT	risk of bias not avaialble
6625	Nasir, 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6625	Nasir, 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6749	Chen_oseltamivir, 2020	1	13	4		not a RCT	high risk of bias
6750	Chen_arbidol, 2020	1	13	4		not a RCT	high risk of bias
6751	Chen_lopi_rito, 2020	1	13	4		not a RCT	high risk of bias
7995	Hazan, 2021	2	32	0	excluded	not a RCT	risk of bias not avaialble
8328	Behera, 2021	0	13	0	selection pending