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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19

Member of the meta|Evidence galaxy

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Treament	Trials
Treament	Trials	Statistically conclusive or suggested result	Inconclusive results	Uncertain results	Safety results
study description meta-analysis results	26 / 38	statistically conclusive 26 % increase in clinical improvement statistically conclusive 17 % decrease in death or ventilation	inconclusive results for: death or transfer to ICU; deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); hospital discharge; mechanical ventilation; ICU admission; recovery; serious adverse events; superinfection; adverse events	-	17 % decrease in death D28 with safety concern statistically conclusive 16 % decrease in deaths with safety concern
study description meta-analysis results	6 / 7	statistically conclusive 31 % increase in clinical improvement	inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement (time to event analysis only); death or ventilation; serious adverse events; adverse events	suggested 86 % increase in clinical improvement (14-day) but the degree if certainty is unassessable	-
study description meta-analysis results	32 / 45	statistically conclusive 26 % increase in clinical improvement statistically conclusive 16 % decrease in death or ventilation	inconclusive results for: death or transfer to ICU; deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); hospital discharge; mechanical ventilation; ICU admission; recovery; serious adverse events; superinfection; adverse events	suggested 86 % increase in clinical improvement (14-day) but the degree if certainty is unassessable	19 % decrease in death D28 with safety concern statistically conclusive 16 % decrease in deaths with safety concern

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

149
treatments

718
studies with results

1743
studies screend

1629
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

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