Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
chloroquine and derivatives4 OBS 0.93 [0.48; 1.81], 1 study, I2=0%
inconclusive result
- 0.84 [0.59; 1.20], 3 RCTs, I2=0%
inconclusive result
-
ivermectin3- 1.51 [0.54; 4.24], 1 RCT, I2=0%
inconclusive result
0.85 [0.50; 1.46], 2 RCTs, I2=0%
inconclusive result
OBS 0.52 [0.10; 2.58], 1 study, I2=0%
inconclusive result
lopinavir/ritonavir2- 1.31 [0.94; 1.83], 1 RCT, I2=0%
inconclusive result
0.81 [0.65; 1.03], 2 RCTs, I2=0%
inconclusive result
-
azithromycin1- 0.74 [0.51; 1.07], 1 RCT, I2=0%
inconclusive result
1.08 [0.79; 1.47], 1 RCT, I2=0%
inconclusive result
-
favipiravir 1-- OBS 1.61 [0.73; 3.58], 1 study, I2=0%
inconclusive result
-
Lopinavir/ritonavir plus hydroxychloroquine1- 0.63 [0.37; 1.06], 1 RCT, I2=0%
inconclusive result
0.58 [0.36; 0.93], 1 RCT, I2=0%
unassessable degree of certainty
-
remdesivir1 0.95 [0.55; 1.64], 1 RCT, I2=0%
inconclusive result
1.23 [0.87; 1.74], 1 RCT, I2=0%
inconclusive result
1.10 [0.49; 2.45], 1 RCT, I2=0%
inconclusive result
-
sofosbuvir and daclatasvir1-- OBS 0.12 [0.02; 0.62], 1 study, I2=0%
unassessable degree of certainty
-
Amantadine0----
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
doxycycline0----
Emtricitabine/tenofovir plus colchicine plus rosuvastatin0----
Ensitrelvir (XOCOVA)0----
favipiravir plus interferon0----
fluvoxamine0----
hydroxychloroquine plus macrolides0----
Interferon plus lopinavir/ritonavir0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
lopinavir/ritonavir, ribavirin and interferon beta-1b0----
molnupiravir0----
niclosamide0----
nirmatrelvir / ritonavir (Paxlovid)0----
nitazoxanide0----
opaganib0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
sofosbuvir0----
sofosbuvir and ledipasvir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
tranilast0----
triazavirin0----
umifenovir (arbidol)0----
zinc0----