Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical deteriorationclinical improvementdeathsviral clearance
Immunosuppressants drugs38 0.48 [0.20; 1.20], 2 RCTs, I2=6%
inconclusive result
1.44 [1.17; 1.78], 8 RCTs, I2=27% demonstrated
moderate degree of certainty
0.81 [0.63; 1.04], 20 RCTs, I2=44%
safety concern
inconclusive result
-
Immunostimulants drugs27 0.63 [0.29; 1.40], 1 RCT, I2=0%
inconclusive result
1.15 [0.96; 1.39], 10 RCTs, I2=48%
inconclusive result
0.74 [0.56; 0.98], 22 RCTs, I2=41%
moderate degree of certainty
6.97 [0.23; 210.35], 2 RCTs, I2=89%
inconclusive result
corticosteroids16 0.66 [0.43; 1.02], 1 RCT, I2=0%
inconclusive result
1.81 [0.89; 3.70], 3 RCTs, I2=72%
inconclusive result
0.81 [0.57; 1.16], 10 RCTs, I2=67%
inconclusive result
-
anti-inflammatory therapies4 0.27 [0.01; 5.58], 1 RCT, I2=0%
inconclusive result
10.27 [1.17; 90.18], 1 RCT, I2=0%
unassessable degree of certainty
0.62 [0.21; 1.90], 3 RCTs, I2=0%
inconclusive result
-
Apilimod0----
inhaled corticosteroids0----
Kinase inhibitors0----
leflunomide0----
meplazumab0----
pirfenidone0----
Polyinosinic-Polycytidylic Acid0----
sargramostim0----
statins0----
thymosin0----